Bone Abstracts

It is well known that osteoporotic fragility fractures are an important risk factor for subsequent new vertebral and non-vertebral fractures. Many countries published recommendations to prevent fractures. Also in Italy the Minister of the Health highlighted the importance to prevent osteoporosis and the subsequent fractures, without practical instructions on the management of patients with fragility fractures in the daily clinical practice. Up to date there is no standardized ...

Collagen barrier membranes are used in guided tissue regeneration to support bone healing and periodontal regeneration. Pharmacological inhibitors of prolyl-hydroxylases (PHD) can support hard and soft tissue regeneration and are therefore a promising tool for periodontal therapy. Here we evaluate the release kinetic of the PHD inhibitors dimethyloxaloylglycine and L-mimosine from the collagen barrier membranes.The PHD inhibitors were lyophilized onto co...

It is well known that thyroid hormone (TH) is essential for normal bone growth and development. However, the mechanisms by which TH regulates these processes are poorly understood. Recently, the sympathetic nervous system (SNS) was identified as a potent regulator of bone metabolism. In vivo studies by our group have shown that TH interacts with the SNS to regulate bone mass and structure, and that this interaction involves α2 adrenoceptor (α2-A...

Success in periodontal regeneration through guided tissue regeneration relies on the healing capacity of the host tissue. Platelet preparations are mitogenic and stimulate regeneration through high growth factor levels. Here we assessed collagen barrier membranes (CBM) as carriers for the secretome of activated platelets. We evaluated cell-attachment, the release of the secretome, and cell proliferation.Secretome of washed platelets (washed PSEC) and unw...

Autosomal Recessive Osteopetrosis (ARO) presents early in life with extreme sclerosis of the skeleton, reduction of bone marrow spaces, hepatosplenomegaly, cranial nerves compression and severe growth failure. ARO is often lethal and at present the only therapy is HSCT, which should be performed as soon as possible in order to obtain a major benefit. ARO is genetically heterogeneous and delays in clinical diagnosis sometimes occur, due to its rareness and to the presence of co...

Introduction: Paget’s bone disease (PBD) is the second most prevalent metabolic bone disease. Most patients present with pain or fracture but many remain asymptomatic. Evidence suggests a significant reduction both in its prevalence and clinical severity. Recent papers described differences in clinical course and therapeutic options in the last 10–15 years.Objective: To characterize PBD differences between patients having been diagnosed before ...

Vertebral fractures are one of the most common and disabling manifestation in osteoporosis. The relationship between bone mass and muscle strength has already been shown in the literature, but only a few studies argues the relationship between BMD and erector spinae muscles. Simple biomechanical considerations suggest that the loss of trunk muscle mass may contribute in vertebral fractures. In the literature, the Soerensen and isokinetic tests are often reported for t...

Metastasis to bone is the leading cause of death for breast carcinoma, and much focus in the biology and therapy relays on epigenetic alterations. Since DNA-methyltransferase blockade counteracts tumour growth, we utilized 5-aza-2′-deoxycytidine (dAza) to clarify whether molecular events undergoing epigenetic control were critical for bone metastatization. Here, we studied Secreted-Protein Acidic and Rich in Cysteine (SPARC), matricellular glycoprotein associated with bo...

Osteogenesis imperfecta is a clinically heterogeneous heritable connective tissue disorder. Most OI cases are due to mutations in type I collagen genes, COL1A1 and COL1A2 encoding the pro-alpha1(I) and pro-alpha2(I) chains respectively. However, genotype-phenotype correlation has not been completely elucidated yet. In this study we evaluated a familial case including a mother and a daughter, classified as OI type I. The daughter had more severe clinical featu...

Introduction: Vertebroplasty (VP) and ballon kyphoplasty (BKP) are used in the treatment of the vertebral compression fractures (VCF), that usually result in a typical wedged deformation. It is still under debate which technique is the best, in terms of efficacy, costs, and safety, mainly about the risk of a adjacent new fractures. The aim of this study is to evaluate the biomechanical outcome of vertebroplasty and kyphoplasty by a computational comparative analysis with finit...