Bone Abstracts

see P410....

Background: On cessation of bisphosphonate treatment, while bone mineral density decreases slowly, bone resorptive markers such as C-terminal telopeptide (CTX) increase more quickly and may be useful in monitoring ‘offset’ of action. Our aim was to analyse changes in CTX on stopping long-term bisphosphonate treatment to guide clinical decision-making on the duration of treatment cessation (‘drug holidays’).Subjects and methods: A tota...

Obesity, diabetes, and high fracture risk is linked, but the mechanism is unclear. However, impaired acute adipose tissue inflammation may be a common denominator for these conditions. Impaired adipose tissue inflammation leads to low adipogenesis, insufficient adipose expansion, and signs of diabetes.The aim of this study was to investigate if the low adipogenesis induced by impaired adipose tissue inflammation is coupled to increased osteoblastogenesis...

Introduction: Aromatase inhibitors (AI) used as adjuvant treatment of hormone-sensitive breast cancer reduce the level of circulating estrogen and cause accelerated bone loss. The aim of this study is to investigate the prevalence of osteoporosis in women with breast cancer and the effect of chemotherapy on the risk of osteoporosis.Methods: Three hundred and sixty women with hormone-sensitive breast cancer who were scheduled to start treatment with AI we...

Evaluation of time-related changes of serum biochemical bone metabolism markers was performed in male pigs. Control group (n=7) received saline. NanoCa group (n=7) received nanopartical calcium per os (Ace Nano Calcium, NanoTechWorld, Korea). Dex group (n=7) received dexamethasone (1 mg/kg/48 hr i.m.). NanoCa/Dex group (n=6) received simultaneously nanopartical calcium and dexamethasone the same as the groups NanoCa and Dex...

Background: Sun exposure may be limited in Arctic populations and Greenland Inuit have adapted to the Arctic environment. The influence of chronic low vitamin D level on PTH to uphold a normal serum calcium remains to be elucidated.Objective: To describe the association between PTH and factors known to influence PTH-, including vitamin D (25OHD) and calcium, in Arctic populations.Methods: Inuit and non-Inuit in the capital city Nuu...

Background: The traditional Inuit diet in Greenland consists mainly of fish and marine mammals. The marine diet is an important source for vitamin D in Greenland. Vitamin D has anti-inflammatory capacity but markers of inflammation were high in Inuit with a high intake of marine food items. Yet, the effect of vitamin D on inflammation in Inuit remains unsettled.Objectives: To investigate the association between vitamin D and markers of inflammation in a ...

Background: We present a case of unusual delayed multi-systemic reaction, following treatment with Pamidronate. The reaction, resembling rhabdomyolysis, requiring intensive care support, has not been reported previously to our knowledge.Presenting problem: An 11 month old boy with severe osteogenesis imperfecta (OI) presented with hyperpyrexia and respiratory distress 10 days after his fifth cycle of Pamidronate. He had significant derangement of his bio...

Objective: We aimed to investigate associations between early-life vitamin D status, mode of infant milk-feeding and bone outcomes at five years.Methods: Participants were from the prospective mother-infant SCOPE-BASELINE Birth Cohort Study. Serum 25 hydroxyvitamin D (25(OH)D) concentrations were quantified at 15 weeks gestation, in umbilical cord sera and at two and five years using a gold-standard CDC-accredited LCMS method. Whole-body bone mineral con...

Cherubism is a rare genetic disease (OMIM #118400) characterized by a massive jaw bone osteolysis. This pathology appears around 2–5 years old and in the less severe cases spontaneously regresses after puberty. So far the only treatment available is surgery, often disabling and traumatic. As the cherubism pathophysiology is not yet understood, we carried out a thoroughly characterization of the cherubism granulomas from ten unrelated patients to determine the cells involv...