Bone Abstracts

Background: The baby growing in its mother’s womb needs calcium for skeletal development. Maternal osteoporosis has been attributed to pregnancy in some cases.Presenting problem: A 27-year-old woman in the 7th month of her first pregnancy complained of mid-thoracic back pain after lifting a non-heavy object. The pain remained with differing intensity and was attributed to her pregnancy. After the delivery of a healthy child, the back pain prevented ...

Background: The relation between sex hormone-binding globulin (SHBG) and vertebral fracture (VFx) is unclear.Aim: To examine whether SHBG is associated with bone mineral density at lumbar spine (LS-BMD), trabecular bone score (TBS) and prevalent VFx.Methods: Data of 6224 men and women participants in the third visit of the first cohort (I-3) and the first visit of the second cohort (II-1) of a prospective population based cohort, w...

Background: Fracture risk is increased in Type 2 diabetes (T2D) individuals. Bone mineral density (BMD) is inversely associated with fracture risk but paradoxically high in T2D individuals. Trabecular bone score (TBS) reflects bone microarchitecture and predicts fracture risk.Objective: We aimed to compare mean lumbar spine TBS (LS-TBS) and lumbar spine BMD (LS-BMD) values, across individuals with and without i) vertebral fracture (VFx), ii) T2D; and iii...

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Objective: We aim to investigate gender similarities and differences in femoral neck (FN) structure of elderly population by bone investigational tookit (BIT) of quantitative computed tomography (QCT).Material and methods: This cross-sectional study was part of China Action on Spine and Hip Status study, including 207 males aged 55–87 years and 400 females aged 55–96 years. QCT scans were performed in the hip for the subjects, and we used BIT s...

Background: Duchenne muscular dystrophy (DMD) is the most common muscular dystrophy in children and it is well known for its progressive deteriorating course. Nowadays, use of glucocorticoids is the gold standard of treatment for this group of patients as it can significantly prolong ambulation, decrease risk of scoliosis, and pulmonary functions. However, the use of glucocorticoid is associated with increased risk of vertebral and lower limb fractures, which could further acc...

Vaspin (visceral adipose tissue-derived serine protease inhibitor) is a newly discovered adipokine that widely participates in diabetes mellitus, polycystic ovarian syndrome and other disorders of metabolism. However, the effect of vaspin on the regulation of osteogenesis and the mechanism responsible are still unclear. Here, we found that vaspin could attenuate the ALP activities, osteocalcin secretion and Runx2 expression in the preosteoblast cell line MC3T3-E1 in a dose-dep...

Objectives: Poor bone health in boys with Duchenne Muscular Dystrophy (DMD) due to muscle weakness and glucocorticoid treatment is a major concern. This study assesses the bone health status in DMD boys with glucocorticoid treatment in a single centre.Methods: A retrospective chart review from January 2009 to January 2017 was undertaken on all DMD cases with active follow-up in a single paediatric unit in a University-affiliated hospital. We assessed the...

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Introduction: Femoral neck fractures and trochanteric fractures are two major types of hip fractures. The BMD changing or hip strength analysis (HSA) of the two type fractures may be different. No research had focused on a large sample of Asian people. This study investigated the differences in BMD and morphologic features of the two type hip fractures of elderly Asian people from QCT.Methods: A total of 279 elderly Chinese patients with hip fractures du...