Bone Abstracts

Preclinical and epidemiologic data suggest that vitamin D deficiency may play a role in the pathogenesis and progression of prostate cancer. Based on recently reported genetic determinants of vitamin D insufficiency we investigated a functional T>G single nucleotide polymorphism (SNP) in the group-specific component (GC) gene for its association with 25-hydroxy (25-OH) vitamin D and 1.25 dihydroxy (1.25-OH) vitamin D levels and further to test a possible association with m...

PTH replacement therapy in hypoparathyroidism (hypoPT) has become more accepted after proving successful in several clinical studies. Intact PTH (PTH1–84) was in 2012 withdrawn, leaving teriparatide (PTH1–34) the only therapeutic option available.All patients with postoperative HypoPT who changed medication from PTH1–84 (100 μg) to PTH1–34 (20 μg), after at least 12 months of conve...

Background: Non-surgical hypoparathyroidism (NS-HypoPT) and pseudohypoparathyroidism (Ps-HypoPT) are both rare diseases, with a prevalence of 2/100.000 and 1/100.000, respectively.Studies on Quality of Life, QoL, are sparse, but studies have shown an increased risk of fatigue and depression.Methods: Using the Danish version of SF36v2 and WHO-5 Well Being Index, we investigated the physical and mental QoL among patients with NS-Hypo...

In previous studies, discrepant effects of TSH and thyroid hormones on bone have been reported. While low TSH and high thyroxine (T4) levels increase bone turnover, a recent study suggested a positive association between triiodothyronine (T3) levels and mineral deposition in bone. No data are available on bone architecture and strength in relation to thyroid status.Aim: Using a cross-sectional design, we determined whether bone dens...

The aim was to explore whether osteoporosis in humans influences the morphological status of the cartilage and subchondral bone, and relationship between macroscopic aspect of the articular surface and the rate of microscopic changes of both the cartilage and the subchondral bone. Femoral heads were obtained from 68 patients with osteoporosis (OP) and hip OA (OP, n=56; OA, n=12) during hip surgery. Evaluation of the cartilage degeneration was done by Mankin g...

Deceased donor kidneys are exposed to cold ischemic insult, which makes them particularly susceptible to the effects of cold ischemic injury during hypothermic preservation resulting in high rates of delayed graft function. Although cold storage reduces cellular oxygen demand, ischemia causes the rapid depletion of adenosine triphosphate and accumulation of toxic substances leading to cell death. BMP-7 is a valuable reagent in a field of tissue regeneration and preservation un...

Conventional treatment of hypoparathyroidism with calcium and active vitamin D analogues causes a high renal calcium excretion and over-mineralized bone.We studied 62 patients with hypoPT randomized to 6 months of treatment with either parathyroid hormone (PTH(1-84)) 100 μg/d s.c. or similar placebo, administered as an add-on therapy. Forty-two of the patients had follow-up test performed after 2.5 years; 9 patients had continued daily PTH treatment...

Background: Hypoparathyroidism (HypoPT) is a rare disease, characterized by low plasma levels of Parathyroid hormone and calcium. Furthermore it is characterized by high BMD and very low bone turnover.Aim: We studied risk of fracture in patients with postsurgical HypoPT due to non-malignant diseases compared with an age- and gender-matched control group.Method: We performed a controlled cohort study. Patients diagnosed with HypoPT ...

Background: DXA scan has for many years been gold standard when analyzing areal bone mineral density (aBMD) in osteoporotic patients. Risk of fractures increases as aBMD declines. However, although risk of fracture is highest in patients with osteoporosis, it is well known that the majority of fragility fractures actually occur in patients with osteopenia rather than osteoporosis. As aBMD is a projected two dimensional imaging technique it does not differentiate between cortic...

see PP210....