Bone Abstracts

Site-specific osteoclasts (OC) and OC-like cells from different pathologies exhibit heterogeneity e.g. in the resorption machinery, influence of anti-resorptive drugs and response to local or systemic hormones e.g. PTH. The explanation for this is not known but different precursors, local regulation through osteoblasts (OB), osteocytes and extracellular matrix (ECM) could be involved. To study these differences a simple and reproducible cell model is an advantage in pre-clinic...

Introduction: Liver transplant candidates have bone and mineral metabolism disorders that may influence the development of fractures after liver transplantation (LT).Objective: To analyze the levels of 25-hydroxyvitamin D (25-OH-D) in patient candidates for LT and the factors associated with vitamin D deficiency.Methods: Between January 2010 and May 2012, 116 liver transplant candidates (85 male and 31 female patients) were include...

Wnt–β-catenin signalling and its antagonists (sclerostin and Dkk-1) play an important role in the regulation of bone mass and osteoblastogenesis. Glucocorticoid therapy (GCCT) is a well known factor related to decreased bone formation and osteoporosis development. Therefore, we analyzed the effect of GCCT on Wnt signalling antagonists (sclerostin and Dkk-1) and their relationship to bone mass and bone turnover.Methods: 22 patients (11M/11F, age...

We recently observed an increased risk for vertebral fractures (VF) in a randomized controlled trial comparing the analgesic effect of vertebroplasty (VP) vs conservative treatment (CT) in symptomatic VF. The aim of the present study was to evaluate the risk factors related to the development of VF after VP in these patients.Methods and results: We evaluated risk factors including age, gender, bone mineral density, the number, type and severity of verteb...

Tartrate resistant acid phosphatase (TRAP) consists of two isoforms TRAP 5a and TRAP 5b suggested to exert different functions and clinical relevance. TRAP 5a is a 35 kDa monomer and a potential marker of inflammatory conditions e.g. atherosclerosis and rheumatoid arthritis. TRAP 5b, a heterodimer of 16 and 23 kDa generated by proteolytic cleavage of a repressive loop in TRAP 5a, is used as marker for osteoclast numbers/bone resorption and osteoclast-related pathological condi...

Spinal cord injury (SCI) has been associated with a marked increase in bone loss. This study analysed the effect of Wnt signalling antagonists (sclerostin and DKK-1) and their relationship with bone turnover markers and BMD evolution in patients with a recent SCI.Methods: Patients with a recent complete motor SCI (AIS A or B); (<6 months) were prospectively included. Bone turnover markers (bone formation: P1NP, bone AP; bone resorption: sCTx), Wnt an...

Background and aims: Low bone formation is the main pathogenic mechanism of osteoporosis in primary biliary cirrhosis (PBC). Sclerostin, an inhibitor of the Wnt pathway, is involved in the regulation of osteoblastogenesis and little is known about its role in the development of bone disease in PBC. Thus, we evaluated the circulating levels of sclerostin and its relationship to bone mass, the parameters of mineral metabolism and liver disease severity.Met...

Spinal cord injury (SCI) has been associated with marked bone loss and an increased risk of fractures under the SCI level. The aim of the study was to analyze the effect of recent complete SCI on bone turnover and bone mineral density (BMD) evolution and factors related to bone loss.Methods: Prospective study including patients with complete motor SCI (ASIA A or B) (<6 months). Bone turnover markers (bone formation: P1NP, bone ALP and resorption: sCT...

The aims of this study were to analyze the role of the regulators of bone remodeling, OPG and RANKL, in the bone loss associated with recent spinal cord injury (SCI) as well as the effect of antiosteoporotic therapy with denosumab in these bone regulators in a prospective study.Patients and methods: Twenty-three male patients (aged 18–67 years (mean 36±16 years)) with recent (<6 months) complete SCI were prospectively included (43.5% parapl...

Background: Besides the classic actions of vitamin D on bone metabolism and calcium homeostasis, there is evidence emphasizing its antiproliferative and proapoptotic activities. Data coming mostly from Northern regions suggest an effect of 25-hydroxyvitamin D (25(OH)D) serum concentrations on breast cancer prevention. We aimed to study the association between 25(OH)D concentrations and breast cancer risk in a Mediterranean population (Spain).Methods: We ...