Bone Abstracts

The bioapatite crystals have a multilayer hydrate shell, which contains impurity ions such as magnesium, sodium, potassium and it is not clear the qualitative and quantitative characteristics of noapatite entourage. The major component noapatite environment in bone is water and we studied the surface of nanocrystals from trabecular bone in healthy rats and during the water deficiency.In experiment we use adult laboratory rats (8 months age), remove the c...

Introduction: We aimed to study efficacy of zoledronic acid (Zol) in the treatment of postmenopausal osteoporosis within 3 years.Methods: Clinical, bone mineral density (BMD) by DEXA (L1–L4, femoral Neck) (baseline, 12, 24, and 36 months); biochemical; immunoenzyme assay of bone turnover markers (BTM) – osteocalcin (OK) β-C-terminal telopeptides of type 1 collagen (CTX) (baseline, 1, 3, 6, 9, and 12 after one, two, three infusions).<p ...

Objectives: This study is aimed at investigating of histological features of mandibular condylar cartilage (MCC) in rats after 2-month inhalation of epichlorohydrin (ECh) vapors and administration of thiotriazoline (Th) and Echinaceae tinctura (ET) as medication.Methods: The experiment involved 420 male rats (young, adult and senile). The animals were split into the groups: 1st group comprised control animals, the 2nd group comprised the animals...

Apart from analyses of well-known correlates of age-related hip fracture risk, such as low BMD, impaired external geometry and deteriorated micro-architecture, there is increasing interest to elucidate nano-structural determinants of fracture risk at the bone mineralized matrix level.In this study we analyzed cortical bone specimens of the femoral neck region in five elderly women who sustained hip fracture and in four healthy women of corresponding age....

Background: The clinical presentation and the clinical phenotypic characterization and the natural history of Fibrodysplasia Ossificans Progressiva (FOP) is diverse and the natural history of the disease is to certain extent different from one patient to another.Methods: In a series of eleven patients age range from 0 to 16 years (eight girls and three boys), variable clinical presentations were the landmark of these patients. At birth, all our patients ...

Objective: Bone fractures are very common in children and their number is growing every year. Vitamin D has a proven role in the prevention of fractures. In the recent study, we have shown that children with low-energy fractures have significantly lower vitamin D blood levels compared to the children without fractures. Our data indicate that higher levels of vitamin D reduced the risk of fracture by 1.06 times (P<0.0005).Past decade has seen...

Research design and methods: A characterisation of 225 European (Russian) osteoporotic postmenopausal women, treated for 2 years with amino-bisphosphonate zoledronic acid (zol), with respect to the adenosine/cytosine (A/C) rs2297480 farnesyl pyrophosphate synthase (FDPS) gene polymorphism, was carried out by PCR-based enzymatic digestion and quantitative PCR allelic discrimination on genomic DNA extracted from blood leukocytes. The association between these polymorphism genoty...

Objective: The enzyme methylenetetrahydrofolate reductase (MTHFR) is known to play an important role in the removal of circulating homocysteine via the methionine cycle. C677T polymorphism is associated with higher plasma homocysteine levels, which could affect collagen maturation. The aim of the present study was to examine possible associations of C677T polymorphism in the MTHFR gene with a variability of femoral (F-BMD), spinal BMD (S-BMD) together with circulating...

It is well known that sex hormone deficiency leads to increased bone turnover and subsequent bone loss. The metabolism of estrogens involves, among others, oxidation (mainly hydroxylation) by CYPs. The aim of this study was to determine whether Leu432Val polymorphism in the CYP1B1 gene is present also in Slovak population and subsequently, if it is associated with femoral and spinal bone mineral density (FBMD and SBMD), bone remodeling markers and fracture incidence in this po...