Searchable abstracts of presentations at key conferences on calcified tissues

ba0006lb7 | (1) | ICCBH2017

Musculoskeletal system in adolescents with type 1 diabetes

Maratova Klara , Soucek Ondrej , Matyskova Jana , Hlavka Zdenek , Petruzelkova Lenka , Obermannova Barbora , Pruhova Stepanka , Kolouskova Stanislava , Sumnik Zdenek

Background: Sarcopenia and osteoporosis are among the late complications of type 1 diabetes (T1D) in adults. Whether and to what extent musculoskeletal impairment is present in childhood and adolescence has yet to be determined. The aim of this study was to assess volumetric bone mineral density (BMD) and dynamic muscle function in adolescents with T1D and to assess the clinical and biochemical predictors of their musculoskeletal system.Methods: Ninety-f...

ba0007lb7 | (1) | ICCBH2019

Validation study of automated bone age assessment in 1285 children and adolescents aged 5 to 16 years

Maratova Klara , Zemkova Dana , Lebl Jan , Soucek Ondrej , Pruhova Stepanka , Kolouskova Stanislava , Snajderova Marta , Krasnicanova Hana , Sumnik Zdenek

Background: Skeletal maturation is the most reliable indicator of biological age in children and adolescents. The evaluation of hand and wrist X-Ray according to Tanner-Whitehouse (TW3) or Greulich-Pyle (GP) are the most commonly used methods for biological age assessment. Automated bone age assessment has recently become increasingly popular, however a large independent study comparing automated and manual evaluation of bone age is still missing. The aim of this study was to ...

ba0005s3.1 | Microbiome and musculoskeletal health | ECTS2016

Gut microbiota and bone metabolism

Ohlsson Claes , Sjogren Klara

The gut microbiota (GM), the commensal bacteria living in our intestine, performs numerous useful functions, including modulating host metabolism and immune status. Our recent studies demonstrate that the GM is also a regulator of bone mass and we propose that the effect of the GM on bone mass is mediated via effects on the immune system, which in turn regulates osteoclastogenesis. A role of the GM in bone metabolism is further supported by studies demonstrating that antibioti...

ba0006pl1 | (1) | ICCBH2017

Poster List

Poster No. Category Title Author P002 Bone development A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation <a href="ba...

ba0003pp28 | Bone biomechanics and quality | ECTS2014

Dietary creatine influence on bone metabolism in rats

Zivny Pavel , Zivna Helena , Svejkovska Klara , Fekete Sona , Holecek Milan

Objective: We investigated the effect of creatine administered in the diet for 10 weeks on bone turnover and bone quality in male Wistar rats.Methods: Rats were divided (after approval of Ethical committee 9814/2008–30 and 30793/2010–30) into four groups, ten animals in each group. G1 SLD-A group were fed a standard laboratory diet (SLD). G2 SLD-B group were fed SLD and 12 h before rats were sacrificed diet was removed. G3...

ba0003pp32 | Bone biomechanics and quality | ECTS2014

Dietary arginine influence on bone metabolism in rats

Zivna Helena , Svejkovska Klara , Fekete Sona , Zivny Pavel , Holecek Milan

Objective: We investigated the effect of arginine administered for 10 weeks in diet on bone metabolism in male Wistar rats.Methods: Rats were divided (after approval of Ethical Committee 9814/2008-30 and 30793/2010-30) into four groups, ten animals in each group: G1 SLD-S group were fed a standard laboratory diet (SLD). G2 SLD-H group were fed SLD and 12 h before rats were sacrificed diet was removed. G3 ARG-S group was fed wit...

ba0005p145 | Cell biology: osteoblasts and bone formation | ECTS2016

Evaluation of release kinetics and mitogenic capacity of collagen barrier membranes supplemented with the secretome of activated platelets

Mozgan Eva-Maria , Edelmayer Michael , Janjić Klara , Pensch Manuela , Fischer Michael , Agis Hermann

Success in periodontal regeneration through guided tissue regeneration relies on the healing capacity of the host tissue. Platelet preparations are mitogenic and stimulate regeneration through high growth factor levels. Here we assessed collagen barrier membranes (CBM) as carriers for the secretome of activated platelets. We evaluated cell-attachment, the release of the secretome, and cell proliferation.Secretome of washed platelets (washed PSEC) and unw...

ba0005p490 | Steroid hormones and receptors | ECTS2016

Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment

Gustafsson Karin , Farman Helen , Lionikaite Vikte , Wu Jianyao , Henning Petra , Andersson Annica , Islander Ulrika , Bernardi Angelina , Windahl Sara , Skrtic Sofia , Sjogren Klara , Koskela Antti , Tuukkanen Juha , Krust Andree , Chambon Pierre , Ohlsson Claes , Lagerquist Marie

It is well established that estrogen, mainly via estrogen receptor alpha (ERα), has positive effects on bone, but estrogen is not considered as a treatment option against osteoporosis due to negative side-effects in other tissues. ERα is widely subjected to posttranslational modifications (PTMs), which can affect cellular responses to estrogen in a tissue specific manner by influencing the function of ERα and its interactions with other proteins. The in vivo...