Bone Abstracts

Background: There are currently 456 rare bone disease recorded within 40 groups. Within many of these diagnoses there is marked heterogeneity of severity and complications that is often not explained by current understanding of disease mechanisms. There is an urgent need to improve the care of these patients by developing novel diagnostic tests and therapies based on understanding sub-phenotypes within existing diagnostic groups.Aim: To develop a nationa...

Fragility fractures including hip fracture are a significant global burden. There is a growing body of evidence that the early environment influences an individual’s risk of fracture. Evidence from longitudinal studies have demonstrated the relationship between measures of body size in early life with later bone mass and risk of fragility fracture. These observations have been extended by parent/offspring cohorts with detailed examination of the maternal environment and s...

Fragility fractures including hip fracture are a significant global burden. There is a growing body of evidence that the early environment influenceS an individual’s risk of fracture. Evidence from longitudinal studies have demonstrated the relationship between measures of body size in early life with later bone mass and risk of fragility fracture. These observations have been extended by parent/offspring cohorts with detailed examination of the maternal environment and s...

Biographical DetailsAfter completing medical training at Charing Cross and Westminster Medical School, I specialized in adult rheumatology at the Wessex Deanery. During that time, I completed a PhD examining the maternal determinants of intra-uterine bone growth as part of an ARC Clinical Fellowship at the University of Southampton. In my last year of clinical training, I was fortunate to...

Pain is common in patients with fibrous dysplasia (FD), however the mechanisms and presentation of pain is poorly understood. Retrospective studies have shown that pain in FD presents along a broad spectrum, responds variably to treatment, and does not correlate with FD disease burden. Pain may be generally conceptualized into two categories: nociceptive pain (associated with actual or potentially tissue damaging stimuli) and neuropathic pain (caused by dysfunction of the soma...

Purpose: To determine the association between socio-economic status (SES) and risk of hip fracture.Methods: Retrospective cohort study. We used a population database which contains primary care and hospital inpatient records of over >5 million people. Anyone registered in this database in 2009–2012 and resident in an urban area was eligible. Main measures: a validated SES composite index (accounting for proportion of unemployed, insufficiently e...

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Objective: Describe UK regional variation in prescription of anti-osteoporosis drug therapy before and after a primary hip fracture during 1999–2013.Materials and Methods: We used primary care data (Clinical Practice Research Datalink) to identify patients with a hip fracture and primary-care prescriptions of any anti-osteoporosis drugs (bisphosphonates, strontium, denosumab, oestrogen therapy, SERMS, teriparatide) prior to primary hip fracture and ...

Objective: Several reports suggest very low persistence with oral bisphosphonates, but there is a scarcity of data on persistence with other anti-osteoporosis medications. We therefore compared rates of early discontinuation (in the first year of therapy) between all available outpatient anti-osteoporosis drugs in Catalonia, Spain.Study design: population-based retrospective cohort study.Participants and source of data: The data in...

Objectives: Bone, muscle and fat share common mesenchymal origins yet current methods separately examine lean, fat and/or bone content. We hypothesized specific musculoskeletal phenotypes derived from relative contributions of each tissue.Methods: Design: We obtained information from the 6-year follow-up of mother–offspring pairs within the Southampton Women’s Survey, a prospective population-based cohort study of 12 583 initially non-pregnant ...