Abstract Search

ba0005p425 | Other diseases of bone and mineral metabolism | ECTS2016

IL-6/STAT3 pathway is critically involved in vascular calcification via histone modification of the RUNX2 promoter in vascular smooth muscle cells

Kurozumi Akira , Nakano Kazuhisa , Yamagata Kaoru , Okada Yosuke , Nakayamada Shingo , Tanaka Yoshiya

Objective: Both inflammation and vascular calcification have been known as independent risk factors of cardiovascular events. However, the induction mechanism of vascular calcification by inflammation is still unclear. We here assessed the molecular effects of pro-inflammatory cytokines on vascular smooth muscle cell (VSMC) calcification.Methods: VSMCs from human aorta cultured in osteoblast induction medium (OIM) and stimulated by pro-inflammatory cytok...

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ba0007p153 | (1) | ICCBH2019

Long-term growth hormone treatment alters glucose metabolism in achondroplasia

Harada Daisuke , Kashiwagi Hiroko , Ueyama Kaoru , Oriyama Kyoko , Hanioka Yuki , Sakamoto Natsuko , Kondo Masafumi Izui Kawai , Nagamatsu Yuiko , Yamada Hiroyuki , Seino Yoshiki , Namba Noriyuki

Objective: To investigate the effect of growth hormone (GH) treatment on glucose metabolism in achondroplasia (ACH) patients.Patients and methods: Twenty-five GH-treated (0.35 mg/kg/week) ACH patients (10 males and 15 females) were included in this study. Oral glucose tolerance test (OGTT) was performed at three time points; pre-treatment (age: 4.0±1.9 years), post short-term treatment (age: 6.5±3.0 years), and pos...

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Bone Abstracts

IL-6/STAT3 pathway is critically involved in vascular calcification via histone modification of the RUNX2 promoter in vascular smooth muscle cells

Long-term growth hormone treatment alters glucose metabolism in achondroplasia

BiosciAbstracts