Searchable abstracts of presentations at key conferences on calcified tissues

ba0007p83 | (1) | ICCBH2019

Could digital X-ray radiogrammetry be an alternative for dual energy X-ray absorptiometry

Leijten Alex , Hampsink Brieke , Janssen Marcel , Klein Willemijn , Draaisma Jos

Objectives: Bone mineral density (BMD) in children is generally measured with dual energy X-ray absorptiometry (DXA). Digital X-ray Radiogrammetry (DXR) is a promising alternative technique, that uses BoneXpert software to measure cortical BMD on hand radiographs, expressed as bone health index (BHI). DXR is a cheap method, is easy to apply in every hospital and involves less ionizing radiation compared to DXA. We aim to compare DXR and DXA measurements for determining bone de...

ba0007p166 | (1) | ICCBH2019

The ketogenic diet and bone density: a retrospective longitudinal cohort study

Draaisma Jos , Hampsink Brieke , Willemsen Michel , Linders Miel , van Houdt Nicole

Background: The Ketogenic Diet Treatment (KDT) is a well-established intervention for intractable childhood epilepsy and the first choice treatment for Gluccose-1-transporter-deficiency-syndrome and Pyruvate-dehydrogenase-complex deficiency. During long-term follow up of children treated with KDT an increased incidence of bone fractures has been found. However, the exact contribution of KDT to a decreased BMD remains unclear. Prophylactic supplementation with calcium and vitam...

ba0006is05biog | (1) (1) | ICCBH2017

Skeletal mineralization – enzymes and animal models

Millan Jose Luis

Biographical DetailsJosé Luis MillánProfessor José Luis Millán received his early training in clinical chemistry and biochemistry at the University of Buenos Aires, Argentina, and his PhD in Physiological Chemistry at the University of Umeå, Sweden, in 1983. Professor Millán is currently based at the Children’s Hea...

ba0002oc28 | Chronic diseases | ICCBH2013

Bone mineral density at diagnosis determines fracture rate in children-treated according to the DCOG-ALL9 protocol

te Winkel Mariel Lizet , Pieters Rob , Hop Wim C J , Roos Jan C , van der Sluis Inge M , Bokkerink Jos P M , Leeuw Jan A , Bruin Marrie C A , Kollen Wouter J W , Veerman Anjo J P , de Groot-Kruseman Hester A , van den Heuvel-Eibrink Marry M

Objectives: To elucidate the incidence and risk factors of skeletal toxicity in children with ALL treated with the dexamethasone-based DCOG-ALL9 protocol.Methods: Prospectively, the cumulative incidence of fractures was assessed in 672 patients and compared between different subgroups using the log-rank test. Serial measurements of bone mineral density of the lumbar spine (BMDLS) were performed in 399 ALL patients using dual energy X-ray absor...

ba0004op11 | (1) | ICCBH2015

Optimal dose of calcium for treatment of nutritional rickets

Thacher Tom , Smith Lauren , Fischer Philip , Cha Stephen , Isichei Christian , Pettifor John

Objective: Nutritional rickets in Nigerian children is primarily due to dietary calcium deficiency and heals with calcium supplementation. Our aim was to determine the optimal dose of calcium for treatment of children with rickets due to dietary calcium deficiency.Methods: At the Jos University Teaching Hospital, 65 Nigerian children with radiographically-confirmed rickets were randomized to daily supplemental calcium intake of 500 mg (n=21), 10...