Bone Abstracts

Inflammatory stimuli can lead to bone loss by mechanisms that are not well understood. We recently showed that skin inflammation induces bone loss in mice and humans. In psoriasis, one of the prototypic IL-17A-mediated inflammatory human skin diseases, low bone formation and bone loss correlates with increased serum IL-17A levels. Similarly, in two mouse models with chronic IL-17A-mediated skin inflammation, K14-IL17Aind and JunB&...

The clinical orthopaedic problem of delayed healing or non-union after complex fractures affects 5–10% of all patients, especially within the elderly population. Recently several in vitro studies showed that CD133+ cells bare angiogenic capacities and contribute to a better outcome concerning ischemia induced angiogenesis in vivo. A local administration of these specific cells to the fracture gap appears feasible as a new treatment option for biological ...

Background: Bone fragility and vascular calcifications are to the two main morbidities of the mineral and bone disorders associated with chronic kidney disease (CKD), resulting from a combination of abnormalities such as impaired GH axis, vitamin D deficiency, hyperparathyroidism, increased FGF23 levels, hypogonadism, denutrition and drug toxicity.Methods: In a single-centre ancillary study of the longitudinal prospective European 4C study (Cardiovascula...