Bone Abstracts

Objectives: Lysophosphatidic acid (LPA) is a potent lipid growth factor which possess several G protein-coupled receptors LPA1-6. We have recently demonstrated that LPA1 receptor-invalidated mice display abnormal bone development and osteoporosis, suggesting abnormal endochondral ossification. We have here further studied the growth plates of LPA1 receptor-invalidated mice.Methods: We performed a microscopic and immuno-histochemistry analysis of the femo...

Chronic tophaceous gout is the natural evolution of untreated gouty arthritis and is characterized by the deposition of solid monosodium urate crystal aggregated in a variety of tissue including joints, bursae and tendons. Tophaceous gout is well-known to cause bone erosions and is characterized by enhanced osteoclasts development. Peripheral blood mononuclear cells (PBMCs) from patients with severe erosive gout showed the preferential ability to transform into osteoclast-like...

Osteoclasts are bone-resorbing multinucleated cells that differentiate from monocyte/macrophage-lineage precursors. Bone destruction and osteoporosis are attributed to excessively activated osteoclasts. Osteoclast differentiation is governed by diverse regulatory processes including nuclear factor-activated T cells c1 (NFATc1) activation in response to RANKL. The mechanism of epigenetic regulation of NFATc1 in osteoclastogenesis not investigated yet. Here we test a hypothesis ...

Receptor activator of nuclear factor kappa B ligand (RANKL)-induced activation of NF-κB and MAPKs signaling pathways is critical to osteoclastogenesis. Glossogyne tenuifolia has been used as an antipyretic, detoxication, and anti-inflammatory herb tea in Penghu Island, Taiwan. This study investigated the effects of G. tenuifolia ethanolic extract (GTE) on the formation of RANKL-activating osteoclasts and expression of signaling pathways using a RAW264.7 ...

Objectives: Adolescent idiopathic scoliosis (AIS) was associated with low bone mass which, apart from being an important health issue that could persist into adulthood, was also a significant prognostic factor for curve progression in AIS. We have performed a randomized controlled trial on whole-body vibration (WBV) and reported its effect on increasing femoral neck areal bone mineral density (aBMD) mainly at the dominant leg. The objective of this study was to evaluate the ro...

Objectives: Multiple studies have documented the presence of systemic osteopenia in adolescent idiopathic scoliosis and in simulated animal models. Osteopenia was also found to be associated with severe curves and as one of the prognostic factor in predicting curve progression in AIS. The objective of this study was to compare the bone quality and its association with osteopenia between AIS and normal controls.Methods: AIS (n=234) and non-AIS gi...

Objectives: AIS is associated with both low bone mass and elevated serum bone alkaline phosphatase. The greater the latitude of the geographical region, the higher is the prevalence of AIS. These specific features were compatible with the presence of either Vit-D insufficiency or abnormal physiology with Vit-D. It is important to evaluate these potentially treatable conditions regarding their roles in the etiopathogenesis of AIS. The objectives of this case-control study were ...

Introduction: Adolescent idiopathic scoliosis (AIS) is associated with osteopenia, which was found to be a significant prognostic factor for curve progression. However, in-depth quantitative assessment of bone quality was previously hampered by invasive nature of the investigations. The recently available high-resolution pQCT (HR-pQCT) allows a three-dimensional assessment of the bone quality in-vivo. This study aimed to evaluate and compare the bone quality in AIS gi...

Objectives: Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional structural deformity of the spine and its etiology remains unknown. Girls with AIS have taller stature, longer arm span, lower BMI, and generalized osteopenia. Leptin has been postulated as one of the etiologic factors of AIS because of its important physiological functions in neuro-osseous development affecting skeletal growth, bone metabolism, energy expenditure and body composition. Previous st...

Objectives: Vitamin D is essential for bone modeling/remodeling but the relationship between vitamin D status, bone mineral density (BMD) and bone quality parameters remains controversial especially in adolescent population. The aims of this study wase to evaluate the vitamin D status and its correlation with BMD and bone quality parameters among adolescent girls in Hong Kong where information is lacking.Methods: 156 adolescent girls (11–15 years ol...