Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp341 | Osteoporosis: treatment | ECTS2014

Changes on bone turnover markers and bone mineral density in women with postmenopausical osteoporosis treated with denosumab

Moro-Alvarez Maria-Jesus , Diaz-Curiel Manuel , Andrade Marjorie , Mahillo-Fernandez Ignacio

Denosumab (DNMB) is an effective treatment for osteoporosis with antiresorptive effect that has demonstrated to increase the bone mass and reduces the incidence of both vertebral and nonvertebral fractures in randomized controlled trials (RCTs).Objectives: To confirm that this drug is actually effective in our experience into daily clinical practice as well.Material and methods: 30 postmenopausal women, mean age 71 years (r</em...

ba0005p109 | Cancer and bone: basic, translational and clinical | ECTS2016

Antiproliferative properties of oleuropein in human osteosarcoma cells

Moran Jose M , Leal-Hernandez Olga , Canal-Macias Maria L , Lavado-Garcia Jesus M , Roncero-Martin Raul , Aliaga Ignacio , Pedrera-Zamorano Juan D

Background: Cancer is one of the leading causes of death worldwide. Natural products have been regarded as important sources of potential chemotherapeutic agents. In this study, we evaluated the antiproliferative activity of oleuropein, an olive oil compound traditionally found in the Mediterranean diet.Design and Methods: The antiproliferative activity on two human osteosarcoma cell lines (MG-63 and Saos2) was evaluated in vitro using the MTT c...