Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp185 | Chondrocytes and cartilage | ECTS2014

Disturbed cartilages of the mandible in achondroplasia are associated with defective mandible shape and position

Duplan Martin Biosse , Di Rocco Federico , Heuze Yann , Gaudas Emilie , Komla-Ebri Davide , Kaci Nabil , Benoist-Lasselin Catherine , Legeai-Mallet Laurence

FGFR3 activating mutations are responsible for achondroplasia (ACH), the most common form of dwarfism. ACH clinical features include short stature, midface hypoplasia, frontal bossing and prognathism and both endochondral and membranous ossifications are disturbed. It is unknown if abnormal mandibles are present in ACH. To date, it is believed that primary (Meckel’s) and secondary (angular and condylar) cartilages play important roles in determining the final shape and po...

ba0003pp375 | Other diseases of bone and mineral metabolism | ECTS2014

Osteoprotegerin and bone-like vascular calcification are predictive markers of vulnerable carotid plaques

Heymann Marie Francoise , Davaine Jean Michel , Laperine Olivier , Merlini Thierry , Guyomarch Beatrice , Chatelais Mathias , Guilbaud Florian , Brennan Meadhbh Aine , Heymann Dominique , Goueffic Yann

Vascular calcification has a marked impact on arterial heterogeneity and plaque stability. Based on a cohort of 116 patients (carotid and femoral endarterectomies), the aim of the present study was to determine the influence of the bone-like vascular calcification and of osteoprotegerin (OPG) on plaque stability.Seventy-three carotid and 43 femoral plaques along with plasma were harvested and analyzed in a single center study. The presence of osteoid met...