Bone Abstracts

Objectives: Low bone mineral density (BMD) is reported frequently in adult cystic fibrosis (CF) patients but the data is less consistent for children and adolescents. The aim of our study is to describe bone mineral density (BMD) in a group of children over a period of 10 years and to determine if BMD is related to vitamin D level, calcium intake, lung function, height and age.Methods: A retrospective review of 123 DXA scans conducted in 50 children with...

A number of cancers develop in the skeleton or will metastasize to bone, including multiple myeloma and solid tumours such as breast and prostate cancer. Once established in the skeleton, cancer cells have the ability to modify the environment and cause devastating bone disease. The last decade has seen considerable progress in defining the critical cellular and molecular mechanisms responsible and also identified new roles for the cells of bone in the pathogenesis of metastas...

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Our skeleton needs to carry the body weight and to resist mechanical impacts. This capability or, conversely, bone fragility are controlled by the amount of bone mass, the shape and internal architecture of the bones, as well as by the material of which they are built. Bone material consists of a complex multi-scale arrangement of mineralized collagen fibrils containing also water, proteoglycans as well as some non-collagenous proteins. This organization is by no means constan...

Biographical DetailsPeter Fratzl is director at the Max Planck Institute of Colloids and Interfaces in Potsdam, Germany, and honorary professor at Humboldt University Berlin and Potsdam University. He holds an engineering degree from Ecole Polytechnique in Paris, France, and a doctorate in Physics from the University of Vienna, Austria. His scientific interests include the relation betwee...

Multiphoton microscopy (MPM) is a powerful approach to visualize live cells and tissues, including bone, in three dimensions and over time. To enable preclinical longitudinal monitoring of bone by intravital MPM we developed an animal window model of bone using existing tissue engineering strategies. Electrospun polycaprolactone scaffolds and human mesenchymal stem cells after osteoblastic differentiation, in vitro, were implanted into the mouse skin in the presence o...

Biographical DetailsEleonora Dondossola is a Senior Postdoctoral Fellow in the Intravital Imaging Lab, Koch Center for Applied Research in Genitourinary Cancers, the University of Texas MD Anderson Cancer Center, Houston, TX, USA. She received her PhD in Cell and Molecular Biology from S. Raffaele Vita-Salute University, Milan, Italy, in 2010. Her current research is focused on metastasis...

Hip fractures in children are extremely rare and account for less than 1% of all fractures in children. Most orthopaedic surgeons will treat only a few such fractures in a lifetime. They are associated with high complication rate because the vascular and osseous anatomy of the child’s proximal femur is vulnerable to injury. Knowledge of the blood supply to the immature proximal femoral epiphysis is necessary to adequately manage these injuries. Hip pain in children is a d...

Abaloparatide (BA058) is a synthetic analog of PTHrP1–34 which greatly increases bone mass and bone strength with preservation of normal bone quality in animal models of osteoporosis. Daily s.c. abaloparatide (ABLSC) at doses of up to 80 μg daily in postmenopausal women with osteoporosis for up to 48 weeks were associated with increases in spine and femoral neck BMD of up to 12.9 and 4.1% respectively and good safety and tolerability. The increa...

According various guidelines the basic recommendation in prevention and treatment of postmenopausal osteoporosis (PMO) is adequate intake of calcium (1000– 1300 mg/day) and vitamin D (800–1000 IU/day).Aim: To determine the intake dose of calcium and also the vitamin D saturation in women treated for PMO.Patients and methods: 465 women with PMO, divided into two groups: patients with newly diagnosed osteoporosis (n</em...