Searchable abstracts of presentations at key conferences on calcified tissues

Bone Abstracts

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ba0003pp3 | Arthritis and other joint diseases: translational and clinical | ECTS2014

Bone loss in patients with early axial spondyloarthritis

Gubar Elena , Bochkova Anna , Smirnov Alexander , Dubinina Tatiana , Diomina Anastasia , Rumiantseva Oksana , Shubin Sergey , Glukhova Svetlana , Erdes Shander

Objective: To examine bone mineral density (BMD) at the femoral neck (FN) and lumbar spine (LS) in patients (pts) with early axial spondyloarthritis (axSpA).Methods: 73 pts (33 men and 40 women) with early axSpA were included in this study. Pts fulfilled ASAS criteria. Pts enrolled in the study had inflammatory back pain for < 5 years: mean disease duration 19.9±14.4 months. Mean age 28.3±6.4 years, mean BASDAI 4.1±1.9; mean ASDAS-CRP ...
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ba0007lb1 | (1) | ICCBH2019

Genetic inactivation of osteocalcin in Col1a1Jrt/+ mice, a model of dominant osteogenesis imperfecta, restores glucose metabolism to wild-type levels

Tauer Josephine T , Komarova Svetlana V

Objective: Osteocalcin, an osteoblast-derived hormone, is among the most abundant proteins in bone and is involved in the regulation of whole-body metabolism, muscle adaptation, and reproduction. High bone turnover and low bone mass are clinical hallmarks of Osteogenesis Imperfecta (OI), a bone disease mainly caused by mutations in the collagen-I gene. Recently, we have shown that growing mice with a severe dominant form of OI, Col1a1Jrt/+ mice, displayed significantly elevate...
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ba0001pp424 | Osteoporosis: treatment | ECTS2013

Acute phase response and zoledronic acid therapy

Yureneva Svetlana , Yakushevskaya Oksana , Smetnik Vera , Sukchich Gennady

Introduction: We aimed to study acceptability of zoledronic acid in the treatment of postmenopausal osteoporosis within 3 years.Methods: Clinical, biochemical, shipping registration at poll by phone and on the subsequent visits.Results: We studied 225 patients with postmenopausal osteoporosis. The patients were treated with zoledronic acid (Zol) 5 mg as a once-yearly infusion within 3 years and 2500 mg of calcium carbonate+800 ME v...
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ba0006p033 | (1) | ICCBH2017

Nutritional status influence upon bone mineral density of children with cerebral palsy after reconstructive hip joint surgery

Kharchenko Svetlana , Popovtseva Anna , Grigoricheva Lyudmila , Lobanov Michael , Kozhevnikov Vadim

Objectives: Evaluate nutritional status influence upon bone mineral density (BMD) of children with CP diagnosis after reconstructive hip joint surgery.Methods: Eighteen children with CP diagnosis with III-V level Gross Motor Function Classification System took part in the research. All patients received reconstructive medical treatment in child traumatic-orthopedic unit of health center after reconstructive hip joint surgery. Anthropometric measurement c...
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ba0003pp312 | Osteoporosis: treatment | ECTS2014

Farnesylpyrophosphate synthase rs2297480 polymorphism and the response to the zoledronic acid in the treatment of postmenopausal osteoporosis

Yureneva Svetlana , Yakushevskaya Oksana , Donnikov Andrey , Kuznetzov Sergey , Mullambaeva Svetlana , Alekseeva Marina , Trophymov Dmitry , Ivanetz Tatyana , Sukhikh Gennady

Research design and methods: A characterisation of 225 European (Russian) osteoporotic postmenopausal women, treated for 2 years with amino-bisphosphonate zoledronic acid (zol), with respect to the adenosine/cytosine (A/C) rs2297480 farnesyl pyrophosphate synthase (FDPS) gene polymorphism, was carried out by PCR-based enzymatic digestion and quantitative PCR allelic discrimination on genomic DNA extracted from blood leukocytes. The association between these polymorphism genoty...
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ba0001pp334 | Osteoporosis: evaluation and imaging | ECTS2013

Bone fragility in patients with alcoholic liver cirrhosis: can hip structure analysis better predict risk of hip fracture

Djonic Danijela , Culafic Djordje , Culafic-Vojinovic Violeta , Ignjatovic Svetlana , Soldatovic Ivan , Vasic Jelena , Djuric Marija

Hepatic osteodystrophy is an important complication of chronic liver disease associated with fractures resulting in pain, deformity and immobility. The aim of the study was to examine association of severity of alcoholic liver cirrhosis with areal bone mineral density (BMD) and to estimate bone geometric strength of the proximal femur in those patinets. The study included 27 male patients with alcoholic liver cirrhosis and control group of 36 healthy patients. Laboratory testi...
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ba0001pp423 | Osteoporosis: treatment | ECTS2013

Three years' experience of zoledronic acid use in the treatment of postmenopausal osteoporosis

Yureneva Svetlana , Yakushevskaya Oksana , Kuznetsov Sergey , Ivanets Tatyana , Smetnik Vera , Sukchich Gennady

Introduction: We aimed to study efficacy of zoledronic acid (Zol) in the treatment of postmenopausal osteoporosis within 3 years.Methods: Clinical, bone mineral density (BMD) by DEXA (L1–L4, femoral Neck) (baseline, 12, 24, and 36 months); biochemical; immunoenzyme assay of bone turnover markers (BTM) – osteocalcin (OK) β-C-terminal telopeptides of type 1 collagen (CTX) (baseline, 1, 3, 6, 9, and 12 after one, two, three infusions).<p ...
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ba0005p150 | Cell biology: osteoblasts and bone formation | ECTS2016

GPR39 is negatively regulating osteoblast differentiation and bone formation during aging

Pesic Milena , Ram Gali Guterman , Orenbuch Ayelet , Katchkovsky Svetlana , Levaot Noam

G-protein coupled receptors (GPCRs) are the largest family of cell surface proteins, which are important for bone development, remodeling and diseases. One of the GPCRs, called GPR39, has been found to be expressed in several osteoblastic cell lines. However, its role in bone metabolism has not been investigated yet. In order to elucidate a role for GPR39, we characterized the bone phenotype in GPR39 deficient mice. During aging, at six months old, dynamic histomorphometry dat...
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ba0006pl1 | (1) | ICCBH2017

Poster List

Poster No. Category Title Author P002 Bone development A 3-year longitudinal study of skeletal effects and growth in children after kidney transplantation <a href="ba...
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Bone Abstracts
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