Bone Abstracts

We have shown previously that TSG–6 acts as an autocrine regulator of osteoclast activity in vitro, capable of inhibiting RANKL-mediated osteoclastic bone resorption with a similar potency to OPG1,2. Thus, the TSG–6 protein has the potential to be developed as a novel treatment for osteoporosis, which is associated with excessive bone loss3.The aim of this study was to determine the therapeutic potential of the is...

Introduction: Perthes disease (PD), idiopathic femoral head avascular necrosis, often results in deformity. The underlying cause is unclear and long-term function is directly related to the roundness of femoral head. Current treatment include mechanical treatments and various surgical procedures, which are therapeutic but can’t prevent collapse. A multicentre, prospective, randomised controlled trial of 12 months zoledronic acid (ZA) in children with PD was conducted. We ...

Purpose: There is no agreed standardised method for assessing vertebral morphology. The algorithm-based qualitative technique appears to be promising in adults to rule out non-osteoporotic fractures and non-fracture deformities, however it has not been previously trialled in children. We aim to modify a technique for use with both dual energy X-ray absorptiometry and radiographs in children, and to evaluate its reliability and reproducibility.Methods: 50...

Purpose: Children have greater lifetime risks of radiation-induced complications compared to adults. In children with osteogenesis imperfecta conventional radiographs are obtained to assess spine morphometry, while DXA assesses bone density. In adults DXA is now used for both. We aim to establish whether iDXA can replace spine radiographs in the assessment of paediatric vertebral morphometry.Methods: An 18-month prospective recruitment of 200 consented c...