Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp236 | Cell biology: osteoclasts and bone resorption | ECTS2013

Osteoclast resorptive surface: correlation of structure and function

Szewczyk Kinga , Fuller Karen , Chambers Timothy

Despite its importance, the resorptive surface of osteoclasts has not been directly visualised. We exploited a novel approach that enables us to inspect the substrate-apposed surface of cells. To achieve this, we incubated osteoclasts on vitronectin-coated nail varnish and, afterwards, we dissolved the substrate and visualised the cells resorbing-side up in the scanning electron microscope (SEM). We then employed confocal microscopy to correlate the SEM appearances with the di...

ba0007p181 | (1) | ICCBH2019

Walking quality of children with healed Perthes disease

Jamil Kamal , Fuller Joel , Li Jamie , Bucknell Michael , McKay Marney , Baldwin Jennifer , Burns Joshua , Munns Craig , Pacey Verity

Objectives: Children with Perthes disease may present with altered walking patterns even at the healed stage of the disease. The aim of the study was to assess the walking endurance, fatiguability and gait changes of children with healed Perthes disease, and to determine if walking endurance is associated with hip function and quality of life.Methods: Fifty-one children (38 males) aged 8–16 years with >3 years post-diagnosis of Perthes disease c...

ba0004p26 | (1) | ICCBH2015

Effects of running bike use on bone quality in non-ambulant children with cerebral palsy: a pilot study

Bryant Elizabeth , Cowan Donna , Walker-Bone Karen

Children with cerebral palsy who are unable to walk independently are prone to lower limb muscle weakness which contributes to pain, deformity and functional loss. As a result of these motor difficulties the children are less physically active than their unimpaired peers and subsequently at greater risk of reduced bone density. This pilot study introduced a novel mobility device, running bikes, to a group of non-ambulant children with cerebral palsy to investigate if it was a ...

ba0007p178 | (1) | ICCBH2019

The role of hydrotherapy in the management of children with severe Osteogenesis Imperfecta

Hupin Emilie , Edwards Karen , DeVile Catherine

Background: Osteogenesis Imperfecta (OI) is most commonly caused by a defect in the genes which produce type 1 collagen. Features of OI include fractures, hypermobility and weakness. Severely affected children can present with deformities such as bowing of long bones and spinal curves. Mobility may be significantly impaired. The medical management of children with severe OI includes orthopaedic surgery and bisphosphonate treatment. Physiotherapy to promote function and partici...

ba0004p46 | (1) | ICCBH2015

Evaluation of the use of a dynamic elastomeric fabric orthosis to improve truncal stability in a young child with osteogenesis imperfecta

Edwards Karen , Hupin Emilie , Cheung Moira , DeVile Catherine

Osteogenesis imperfecta (OI) is most commonly caused by a defect in the gene that produces type I collagen. Features include fractures and ligamentous laxity. Reduced muscle tone is often seen, which can result in gross motor delay in younger children.Dynamic elastomeric fabric orthoses (DEFOs or lycra garments) are widely used in children with low truncal muscle tone, have been shown to improve posture, and increase stability. There is no research in th...

ba0004p151 | (1) | ICCBH2015

Do children with mild to moderate osteogenesis imperfecta (OI) with abdominal muscle weakness have a higher incidence of pars defects? A physiotherapy pilot

Hupin Emilie , Edwards Karen , Chueng Moira , Allgrove Jeremy , DeVile Catherine

Objective: Osteogenesis imperfecta (OI) is most commonly caused by a defect in the genes that produce type I collagen. Clinical features include low bone mass, fractures and spinal abnormalities. Pars defects are abnormalities in the pars interarticularis of vertebrae. There is a higher incidence of pars defects in the lumbar spine in children with OI compared to the normal population. Abdominal muscle weakness and altered spinal postures are common presentations in the childr...

ba0005p319 | Osteoporosis: evaluation and imaging | ECTS2016

CORTEX; catching osteoporosis on routine tomography as an added EXtra

Barnes Polly , Blesic Karen , Johannesdottir Fjola , Skingle Linda , Poole Ken

Risk factors for osteoporosis are often present among patients referred for diagnostic CT scans. Recent UK Clinical Guidelines (NICE-CG146) promote the initial use of FRAX in the majority of patients at risk of osteoporotic fracture, in any health setting. We gained approval and NHS Innovation funding for a pilot service whereby patients undergoing a routine clinical CT scan of the abdomen or pelvis could be screened by estimating their 10-year fracture risk. Patient and radio...

ba0004is16biog | (1) (1) | ICCBH2015

Growth plate and diseases of calcinosis

White Ken

Biographical DetailsKen White, PhD is the David D Weaver Professor of Genetics in the Department of Medical and Molecular Genetics at the Indiana University School of Medicine in Indianapolis, IN, USA. He serves as Director of the Division of Molecular Genetics and Gene Therapy. Dr K White’s research interests focus on the molecular genetics of metabolic bone diseases in regards to p...

ba0001pp268 | Genetics | ECTS2013

No mutations in the serotonin related TPH1 and HTR1B genes in patients with monogenic sclerosing bone disorders

Boudin Eveline , Jennes Karen , de Freitas Fenna , Tegay David , Mortier Geert , Van Hul Wim

Since the identification of LRP5 as the causative gene for the osteoporosis pseudoglioma syndrome (OPPG) as well as the high bone mass (HBM) phenotype, LRP5 and the Wnt/β-catenin signalling have been extensively studied for their role in the differentiation and proliferation of osteoblasts, in the apoptosis of osteoblasts and osteocytes and in the response of bone to mechanical loading. However, more recently the direct effect of LRP5 on osteoblasts and bone formation has...

ba0001pp272 | Genetics | ECTS2013

Comparison of gene expression in osteoblasts from patients of Polynesian and Caucasian ethnicities

Naot Dorit , Bava Usha , Choi Ally , Callon Karen , Pitto Rocco , Bentley Jarome , Gamble Greg , Cornish Jillian

Polynesians have higher bone mineral density and lower rate of hip fracture compared to age-matched Caucasian in New Zealand, and anecdotal evidence suggests that bones of Polynesian patients heal much faster than those of Caucasians. We compared gene expression in osteoblasts cultured form bone samples taken from patients of Polynesian and Caucasian origin, in order to identify genes and pathways that contribute to the greater density and accelerated healing of Polynesian bon...