Bone Abstracts

Background: Bone mass density (BMD) test is used for diagnosing osteoporosis and identifying patients at high risk for fractures. Hip fractures are one of the possible negative outcomes of osteoporosis. Previous studies have examined demographic variations in osteoporotic hip fractures in ethnic groups, but the predictive value of BMD for future fracture is unknown.Objective: To determine whether a BMD test is associated with a lower risk of first hip fr...

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Osteoporotic fractures are very common and represent an enormous unmet medical need. Our group has previously reported that addition of rTNF to the fracture site promotes fracture healing in C57/BL6 mice (Glass et al. PNAS 2011). Using a murine fracture model of endochondral healing, we observed that local addition of rTNF only accelerates fracture repair if administered within the first 24 h following injury. The optimal therapeutic dose is 1 ng. TNF is firs...