Bone Abstracts

Objectives: Special dual-energy X-ray absorptiometry (DXA) protocols permit quantification of bone mineralization, fat mass, and fat distribution in infants. Our objective was to evaluate the accuracy and precision of a multiscan acquisition protocol designed to allow for reflection and imputation analysis for regions with movement.Methods: The IMPAACT P1084s Study assesses bone and kidney safety of antiretrovirals used for PMTCT. Newborns received a spi...

Objective: Endothelial progenitor cells (EPCs) have the potential ability to differentiate into vascular endothelial cells and osteoblasts for angiogenesis and osteogenesis, however, the correlation between number and population of bone marrow EPCs with bone mass and bone metabolism in elderly is unknown.Methods: Trabecular bone were extracted from 11 patients with fragility fracture and eight patients with osteoarthritis during artificial hip replacemen...

Objective: Endothelial progenitor cells (EPCs) have the potential ability to differentiate into vascular endothelial cells and osteoblasts for angiogenesis and osteogenesis, however, the correlation between number and population of bone marrow EPCs with bone mass and bone metabolism in elderly is unknown.Methods: Trabecular bone were extracted from 11 patients with fragility fracture and eight patients with osteoarthritis during artificial hip replacemen...

Effective treatments are available to reduce fracture risk in patients with postmenopausal osteoporosis. Though factors have been identified that modify the effect of treatment with one or more the currently available drugs, as a rule patients will benefit more from treatment the higher their base risk of fracture. From a societal and clinical point of view it is surprising that many guidelines for postmenopausal osteoporosis do not target treatment to patients at the highest ...

Background: Bisphosphonates are widely used to prevent and treat osteoporosis. Limited evidence suggest that these drugs may reduce mortality, perhaps by protecting against cardiovascular disease. This study investigated the occurrence of heart failure in patients treated with bisphosphonates.Methods: Nationwide retrospective cohort study from Denmark. All users of bisphosphonates and raloxifene (n=4.831) between 1996 and 2006 (n=102.34...

see PP398....

Introduction: Osteoporotic fractures are known to be costly to society but estimates tend to be based on small scale prospective studies. In the following we report national data for healthcare costs due to fractures in patients with osteoporosis.Study population and methods: All Danish residents aged 35+, mean age 70.5 years, 13% men, 27.3% prior major osteoporotic fracture, who began bisphosphonates for osteoporosis between 1/1997 and 12/2002 (n</e...

see PP380....

Introduction: Communication of absolute and relative risks is challenging despite the development of tools to quickly derive absolute fracture risk estimates from risk factors with or without BMD. We speculated that back-transformation of risks to a risk age could make for a clearer message and at the same time increase agreement between risk algorithms.Results: The algorithms differed less in estimated bone health age than in percent risk. A 60 years ol...

The origin of the recent levelling-off in hip-fracture incidence in several settings is unknown.Methods: Using Danish national inpatient data for individuals aged ≥50 years during 1980–2010, we examined annual number and incidence of hip fractures and age, period, and cohort effects by log-likelihood estimates in Poisson regression models. Age adjustment was done by direct standardization, time-trend analysis by linear regression, and identifi...