Bone Abstracts

Few interventions directly compare equivalent calcium and vitamin D from dairy vs supplements on the same bone outcomes.Objectives and Methods: Using 41Ca tracer techniques, determine if 4 servings/d of dairy foods reduces Ca excretion more than an equivalent amount of Ca and vitamin D from supplements. Secondary objective was to evaluate the time course for change in Ca excretion.Design: In this crossover trial, postmen...

Osteoporosis in premenopausal is dominated by secondary causes, among which anorexia nervosa, the female athletic triad, celiac disease, and glucocorticoid-induced osteoporosis (GIO) constitute the most frequent conditions. Stress fractures of the lower extremities and low energy fractures of the ribs, are also frequent. Various genetic causes like osteogenesis imperfecta tarda are probably underdiagnosed and various inflammatory conditions also play a role. A rare, but often ...

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Background: Bisphosphonates are widely used to prevent and treat osteoporosis. Limited evidence suggest that these drugs may reduce mortality, perhaps by protecting against cardiovascular disease. This study investigated the occurrence of heart failure in patients treated with bisphosphonates.Methods: Nationwide retrospective cohort study from Denmark. All users of bisphosphonates and raloxifene (n=4.831) between 1996 and 2006 (n=102.34...

Context: Previous impact microindentation studies have demonstrated that osteoporosis patients exhibit impaired bone material strength, which may contribute to skeletal fragility. Whether the impact differs between subtypes of fractures has, however, not been evaluated yet.Objective: To test whether impaired bone material properties differ between different subtypes of osteoporotic fracture and assess how this property relates to fracture severity.<p...

Insulin-like growth factor 1 (IGF-1) is known to be a predictor of future osteoporotic fractures. Insulin-like growth factor binding protein 1 (IGFBP1) regulates the bioavailability of IGF-1 and thus in reason IGFBP1 also could be a fracture predictor. To our knowledge there are no previous studies published on the relation between the serum concentration of IGFBP1 and fractures.This is a population-based prospective cohort study on 351 Swedish women age...

Bone marrow lesions (BMLs), previously denoted bone marrow edema are detected as water signals on MR scans (low intensity on T1 weighted images and high intensity on T2 weighted scans). Previous histologic studies were unable to demonstrate any edematous changes at the tissue level, which led us to hypothesize that the water signal stems from increased vascularization accompanying a high turnover state in bone. To test this hypothesis we performed tetracy...

Introduction: Cathepsin K is necessary for bone matrix resorption. Excessive resorption associated with osteoporosis and osteoarthritis can be reduced by cathepsin K inhibition. MIV-711, a highly selective cathepsin K inhibitor, successfully attenuates both bone resorption and cartilage degradation in non-clinical studies.Aim: To determine safety, tolerability, pharmacokinetics and pharmacodynamics of MIV-711 during multiple oral dosing to postmenopausal...

Objective: To evaluate prevalent risk factors, medication use and comorbidities with bone mass findings at the total hip, femoral neck and lumbar spine.Design: Historical cross-sectional study.Methods: A total of 6285 women and 565 men consecutively referred to an osteoporosis specialist clinic from 2000 to 2012 were included. Information of potential risk factors was obtained from a clinical database. Additional information on med...

Objectives: Postural balance and gait speed are risk factors for falls and hip fractures independent of bone mineral density (BMD). The standard risk assessment tool, FRAX, does however not include any estimate of fall risk. Identifying high-risk individuals correctly is be of great clinical importance why further improvement of FRAX would be clinically valuable. The primary aim of this study was to see if one-leg standing time, the maximum number of steps on a line or gait sp...