Bone Abstracts

Background: Prader Willi syndrome (PWS) is a genetic disorder characterized by severe hypotonia in infancy, hypogonadism, dysmorphic features, early onset obesity and mild mental retardation.Although hip dysplasia occurs in 10–20% in patients with PWS, hip dislocation requiring surgery is seen rarely. To our knowledge, surgical treatment of hip dislocation in PWS has not been reported before.We present a case with PWS and hip ...

Introduction: Paget’s disease of bone (PDB) is a common disorder characterised by increased and disorganised bone remodelling. Previous genome wide association studies identified a locus for susceptibility to PDB on chromosome 1p13, tagged by rs484959 which lies 87 kb upstream of the CSF1 gene. This is a strong candidate for PDB since it encodes macrophage colony-stimulating factor (M-CSF) a critical cytokine for osteoclast formation and survival.Pu...

Low levels of 25-hydroxyvitamin D have been documented among inhabitants of the wider Middle East and North African countries. Sunlight has long been recognized as a major provider of vitamin D. In this study we aimed to determine the optimum time for sun exposure in the Central region of Riyadh, Saudi Arabia. Ampoules containing 7-dehydrocholesterol in ethanol were exposed to sunlight every hour starting from sunrise until sunset in July and December. Our results demonstrated...

The combined effect of lifestyle physical activity (PA) and sedentary behavioral practices on musculoskeletal health in growing populations is still poorly understood. Objectives: To investigate the combined influence of mechanical loading of weight-bearing PA (WBPA) and screen-based sedentary practice (SSR) on musculoskeletal profiles among 455 adolescents aged 12–19 years.Methods: Validated PA and SSR behaviour assessments w...

Osteoporosis is the commonest worldwide age-related bone disease. It is clinically symptomless until the first fracture happens. Circulating microRNAs can be used as novel biomarkers to assess health status and progression of complex diseases. A recent review highlighted the involvement of microRNAs in the control of bone formation and remodeling. Most of these studies have been done on animal models, but few on human blood samples.This research aims to ...

Delta-like 1/fetal antigen-1 (DLK1/FA1) is a negative regulator of bone mass in vivo as it inhibits osteoblast (OB) and stimulates osteoclast differentiation. However, the molecular mechanisms underlying these effects are not known. Thus, we studied the effect of DLK1/FA1 on different signaling pathways known to regulate OB differentiation. We identified DLK1/FA1 as an inhibitor of BMP2-induced OB differentiation. Stable overexpression of DLK1/FA1 in C2C12 cells or th...

Introduction and aim: Vitamin D plays an important role in bone growth. In children, low levels can cause rickets. In adults, low levels can lead to osteoporosis and fragility fractures. The aim of this survey was to get information about vitamin D levels in Lebanese population.Subjects and methods: Serum 25-hydroxy vitamin D level is considered to be the best indicator of vitamin D status. 13 000 subjects included in this study were coming for routine c...

There is a similarity of the mechanisms of physiological and pathological mineralization. Pathological calcification of soft tissues as the case of vascular calcification is characterized by the deposition of hydroxyapaptite induced by matrix vesicles at least in the initial stage as in the case of physiological calcification in skeletal tissues. Lipid metabolism is involved in the differentiation of smooth muscle cells and bone cells suggesting that phospholipases can modulat...

Introduction: Bone is a dynamically changing organ. Reduction of mechanical loading on bone inhibits bone formation and accelerates bone resorption. Prolonged immobilization in casts, therapeutic bed rest and application of external fixations to treat fractures are common causes of disuse osteoporosis.Case Report: We report a case of striking osteoporosis in a 11 years old Syrian boy with a complex open right leg wound following a blast injury (24.03.201...

see PP149....