Bone Abstracts

Low bone mass is common in thalassemia (Thal) and sickle cell disease (SCD). Bone pain is also reported, though its relationship to low bone mass has not been explored. The aims of this study were to determine the prevalence of vertebral height abnormalities (VHA) and evaluate the relationship between VHA, low bone mass and patient assessed pain in Thal and SCD. Data were collected from the Thalassemia Clinical Research Network Pain Survey study and CHRCO Clinical Bone Density...

Thalassemia (Thal) is a genetic disorder of hemoglobin synthesis. In its most severe form patients require chronic blood transfusions to sustain life leading to iron overload unless excess iron is removed by chelators. Deferasirox (DFX) and deferoxamine (DFO) are the two most common chelators. DFX has recently been shown to reduce osteoclast activity in vitro.Objective: To explore the association between chelation therapy, bone density and verte...

Poor bone mineralization remains a major health problem in patients with Thal and has been linked to functional zinc deficiency despite adequate dietary intake. The global etiology of poor bone mineralization includes inadequate dietary intake of calcium and vitamin D, endocrinopathies leading to disturbed calcium homeostasis, dysregulation of the GH–IGF1 axis, and delayed puberty, all resulting in limited growth, decreased bone formation and increased bone resorption. Th...

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Background: Mechanical stimulation is thought to be critical for bone anabolic activity. It is unclear how quickly the growing skeleton responds to additional externally-applied mechanical stimuli. We wished to determine the acute effect of a standardised mechanical stimulus to the growing skeleton.Objectives: To determine the acute time course and magnitude of bone’s response to whole body vibration (WBV) in pre-pubertal boys.<p class="abstext"...

Objectives: Adolescent idiopathic scoliosis (AIS) was associated with low bone mass which, apart from being an important health issue that could persist into adulthood, was also a significant prognostic factor for curve progression in AIS. We have performed a randomized controlled trial on whole-body vibration (WBV) and reported its effect on increasing femoral neck areal bone mineral density (aBMD) mainly at the dominant leg. The objective of this study was to evaluate the ro...

Objectives: AIS is associated with both low bone mass and elevated serum bone alkaline phosphatase. The greater the latitude of the geographical region, the higher is the prevalence of AIS. These specific features were compatible with the presence of either Vit-D insufficiency or abnormal physiology with Vit-D. It is important to evaluate these potentially treatable conditions regarding their roles in the etiopathogenesis of AIS. The objectives of this case-control study were ...

Objectives: Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture, but the etiology of this disposition is unknown. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS.Methods: This was a cross-sectional study of 10 children (9 females) ages 8-18 years, with a clinical diagnosis of ALG...

Objectives: Vitamin D is essential for bone modeling/remodeling but the relationship between vitamin D status, bone mineral density (BMD) and bone quality parameters remains controversial especially in adolescent population. The aims of this study wase to evaluate the vitamin D status and its correlation with BMD and bone quality parameters among adolescent girls in Hong Kong where information is lacking.Methods: 156 adolescent girls (11–15 years ol...