Bone Abstracts

Damages of bones of facial skeleton lay down 8% from all damages, fractures of mandible are 85–90% from it. There are a lot of factors, that make worse the process of reparative regeneration of bone. Using of nitric fertilizers lead to heighten earning of nitric oxide into organism. It makes negative influence on reparative regeneration of bones.There are dates of research of 40 rats line Vistar in this article. The goal of this study was to examine...

Objectives: Frequency of occurrence of forearm deformations developed against the background of a hereditary multiple exostosis (HME) in children reaches 30–80%. The clinical and radiological data of forearm deformities have not been sufficiently researched yet. The purpose of our research is specification of children’s forearm deformities developed against the background of HME.Methods: Retrospectively and prospectively we selected and analyze...

Objectives: To determine any relationship of serum concentrations of osteoprotegerin (OPG), sRANKL and sRANKL:OPG ratio with idiopathic hypercalciuria (IH) in children, as there is some evidence of increased bone resorption in these patients.Methods: In a prospective study, twenty four children of median age 6.5 years (range 2.3–16.4) with IH (five had urolithiasis and two nephrocalcinosis) were examined at the time of diagnosis and after 3 months o...

Objective: To study any possible relations of vitamin D status and metabolic syndrome (MetS) components in children, since there is evidence for extraskeletal functions of vitamin D, and its deficiency may contribute to the pathogenesis of several major diseases. In addition to explore any possible role of birth weight (BW).Methods: Clinically healthy children aged 3–9 years (n=152) were included in the study. Forty-six were born large for ...

Background: Optimal intake of calcium and vitamin D of pregnant women is an important component for the normal course of pregnancy, but here are the contradictory opinions about the case of shortage of the consumption, there is no uniform approach to the appointment of them.Aim: To assess the level of consumption of alimentary calcium, and characteristic of the status of vitamin D and calcium in blood serum of pregnant women.Materi...

Objectives: We evaluated the efficacy and safety of intravenous zoledronic acid (IV ZA) in children with glucocorticoid-induced osteoporosis (GIOP) through a randomized, placebo (PBO)-controlled trial.Methods: In this multi-national Phase 3 trial (NCT00799266), children 5–17 years of age with GIOP and low-trauma vertebral fractures (VF) were randomized 1:1 to IV ZA 0.05 mg/kg or IV PBO every six months for one year. Changes in lumbar spine areal bon...

The study is aimed to evaluate body composition and bone status in adult patients with active juvenile idiopathic arthritis (JIA) untreated with tumor necrosis factor α inhibitors. Adult patients (12 males and 19 females) with JIA and 84 healthy age- and gender- matched controls were enrolled into the study. Body composition and areal bone mineral density (aBMD) at the lumbar spine, proximal femur, femoral neck, distal radius and total body were assessed using dual energy...

Introduction: Collagen induced arthritis (CIA) is a mouse model of rheumatoid arthritis marked by persistent inflammation and enhanced osteoresorption at the affected joints as well as systemic osteopenia due to increased activation of osteoclast progenitors (OCP). Abundantly secreted chemokines presumably attract OCPs to the inflamed sites. Our goal was to identify chemotactic signals important for OCPs recruitment in CIA.Methods: After obtaining approv...

Objectives: Previous studies indicate that about half of boys and one fourth of girls suffer a fracture before the age of 16 years. Similarly, children of European descent are more prone to fracture. Here we aimed to investigate at the population level the influence of sex, ethnic background and bone mineral density (BMD) on the occurrence of bone fractures in children of school age.Methods: This study (n=3,633 children with complete information...

Background: Low total body BMD (TB-BMD) is an established risk factor for fractures in healthy children. However, bone strength depends not only on bone mass and density, but also on the structural geometry of bones. Hip structural analysis (HSA) is a technique applied on hip DXA scans to calculate several bone geometry parameters. The aim of our study was to evaluate other bone geometrical parameters that can constitute determinants of fracture risk. Specifically, we examined...