Bone Abstracts

Objectives: Burosumab is an anti-FGF23 fully human monoclonal antibody, recently approved for the treatment of X-linked hypophosphatemia (XLH), presenting a novel treatment approach compared to conventional therapy (CT), composed of oral phosphate and active vitamin D. The objective of this study is to perform a Multi-Criteria Decision Analysis (MCDA) to assess the value of burosumab for the treatment of paediatric patients with XLH in Portugal, in comparison to CT.<p clas...

Objectives: Achondroplasia, the most common form of short limb dwarfism, is a rare genetic disorder caused by a gain-of-function mutation of the FGFR3 receptor (FGFR3-G380R) and there are currently no effective treatments available. We have developed TA-46, a recombinant human soluble FGFR3(sFGFR3) form of the FGFR3 cell surface receptor containing an extra-cellular ligand-binding domain, including three IgG domains, which confer binding specificity. TA-46 is designed to block...

Objective: Since depressive symptoms, which have been related to low bone quality in adulthood, may also be associated with suboptimal bone mineral accrual, we aim at quantify the association between depressive symptoms and bone mineral density (BMD) throughout adolescence.Methods: We analysed prospective data from 969 adolescents (56.2% girls) from a population-based cohort of urban adolescents, born in 1990, evaluated during the 2003/2004 and 2007/2008...

Objectives: By prospectively evaluating a cohort of girls we aim to identify population patterns linking adipokines and bone turnover during early and late adolescence and to assess the associations of those patterns with forearm bone mineral density (BMD).Methods: The study was developed within a population-based cohort of urban adolescents born in 1990 and assembled in public and private schools of Porto, Portugal (EPITeen). We analysed prospective dat...

The body mass index has been regarded as a risk predictor factor for fractures, and in some prospective cohort studies it has been suggested that obesity could be a protective factor for hip fractures in adults.The present study aimed to investigate whether body mass index is related to the fracture risk when individuals had sideways falls in Mexican patients. We analyzed files from 448 patients, which checked in at Orthopedics and Traumatology Service i...

Gla-rich protein (GRP) is a vitamin K-dependent protein, characterized by a high density of γ-carboxylated Glu residues and high calcium binding affinity. It was shown to accumulate in mouse and sturgeon cartilage and in sites of skin and vascular calcification in humans. Four alternatively spliced transcripts of the GRP gene (GRP–F1, F2, F3 and F4) were described in mouse chondrocytes and zebrafish. Osteoarthritis (OA) is a common degenerative joint disease...

Background: Zoledronate, a third generation bisphosphonate, has showed high efficacy in the inhibition of bone resorption. The objective of this observational study was to assess short and long-term efficacy and safety of zoledronate in the treatment of active Paget’s disease (PD).Methods: Patients with active PD treated with zoledronate 5 mg were consecutively recruited. Clinical and laboratory parameters were determined before, at 3 and every 6 mo...