Bone Abstracts

Fibroblast growth factor-23 (FGF23) is a major regulator of phosphate metabolism often elevated in genetic hypophosphataemic disorders and in chronic kidney disease–bone mineral disorder (CKD–BMD). Recent studies have identified relationships between FGF23 and vitamin D.Objectives: To determine the relationship between vitamin D and FGF23 metabolism in CKD.Method: We used randomized samples from patient...

Supported by Alexion & IDS)-->Low vitamin D serum levels have been associated with a considerable number of diseases and conditions and have attracted significant attention of the scientific community as well as of health authorities all over the world. However, discussions and controversies are ongoing about the reliability, significance and correct ranges of low vitamin D serum levels. A central goa...

Introduction and aim: Vitamin D plays an important role in bone growth. In children, low levels can cause rickets. In adults, low levels can lead to osteoporosis and fragility fractures. The aim of this survey was to get information about vitamin D levels in Lebanese population.Subjects and methods: Serum 25-hydroxy vitamin D level is considered to be the best indicator of vitamin D status. 13 000 subjects included in this study were coming for routine c...

Background: Vitamin D plays an important role in calcium and phosphate homeostasis. Circulating 25 hydroxyvitamin D [25(OH)D] is metabolised into its biologically active form 1,25-dihydroxyvitamin D [1,25-d(OH)D] by the actions of 1α hydroxylase, and into inactive 2metabolite 24,25-dihydroxyvitamin D [24,25-d(OH)D] by 24-hydroxylase. Recent studies suggest the production of 1,25-d(OH)D) from 25(OH)D is 24,25-d(OH)D dependent. Genetic mutations of CYP24A1 gene resulting in...

In Canada, and many other countries, a vitamin D supplement of 400 IU/day is recommended for breastfed infants and staple foods are fortified with vitamin D in accordance with public health policy for the primary prevention of rickets. Both vitamin D receptors and 1-alpha hydroxylase enzymes are expressed in human muscle, implicating vitamin D status and metabolism in growth and development. In a randomized dose response study of vitamin D supplementation (400, 800, 1200, or 1...

Vitamin D deficiency in pregnancy is common, and is linked to increased risk of adverse outcomes including preterm birth, preeclampsia, infection, gestational diabetes and asthma. Vitamin D possesses well-recognized immunomodulatory functions, and programming of the immune system during foetal development can influence asthma-related risk factors and health outcomes in later life. We hypothesized that influencing vitamin D status during pregnancy would impact the immune profil...

Objectives: Vitamin D intake at a dose 400 IU/d is recommended for breastfed infants and is considered as sufficient. Vitamin D status is connected with bone mass and fat mass. We aimed to assess, if 400 IU/d has the same efficiency and impact on body composition in infants with different vitamin D status at birth (<20 ng/ml vs ≧20 ng/ml).Methods: 148 breastfed infants were supplemented with 400 IU/d of cholecalciferol up to 6 months of age. S...

Vitamin D deficiency is common in aging people and is associated with secondary hyperparathyroidism, bone loss, osteoporosis and fractures in epidemiological studies. Vitamin D3 is produced in the skin through u.v. irradiation of the sun in spring and summer, and it can also be obtained from food, especially fatty fish, such as herring or mackerel. Vitamin D is activated by liver and kidney. Its main action is stimulation of calcium absorption from the gut. Vitamin ...

Introduction: Liver transplant candidates have bone and mineral metabolism disorders that may influence the development of fractures after liver transplantation (LT).Objective: To analyze the levels of 25-hydroxyvitamin D (25-OH-D) in patient candidates for LT and the factors associated with vitamin D deficiency.Methods: Between January 2010 and May 2012, 116 liver transplant candidates (85 male and 31 female patients) were include...

Objective: To investigate the relationship of frailty with vitamin D in community dwelling elderly women.Materials and methods: A retrospective cross-sectional study was performed on women over 60 years who were not using vitamin D supplementations. Frailty status was defined using Fried’s criteria: weakness, low walking speed, low physical activity, weight loss, exhaustion. Participants were classified as robust, prefrail and frail if they scored 0...