Bone Abstracts

Introduction: Norway has one of the highest reported incidences of osteoporotic fracture. Since, bone mineral density (BMD) is a strong predictor of future fracture risk, high peak bone mass achievement is essential. This study is the first to examine BMD in a population-based study including Norwegian adolescents. Here we compare the measured BMD with international reference ranges and explore predictors of BMD in this population.Methods: In 2010–2...

Background: Osteogenesis imperfecta (OI) is a hereditary connective tissue disorder characterized by increased bone fragility and low bone mass. The different types of OI may be distinguished by their clinical features and the causative genes, with COL1A1 and COL1A2 genes as the most frequent. The guidelines for OI genetic diagnosis first recommends the screening of COL1A1 and COL1A2 genes using Sanger sequencing. However, this method has li...

Introduction: Recent studies have found anti-inflammatory, antioxidant and bone forming properties of green (GTP) and black tea (BTP) polyphenols. However most of these studies are focussed on specific genes or pathways. We wanted to know if GTP and BTP could help to reduce symptoms of chronic inflammation especially bone loss and what are the possible genes and pathways involved. We were especially interested in unexplored pathways which may play a role in regaining bone heal...