Bone Abstracts

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Radiation therapy is one of the most effective and indispensable treatment modalities for cancer patients. Known tissue complications caused by radiation-induced stem cell depletion, may result in structural and functional alterations of the surrounding matrix. Although, studies have demonstrated that ionizing radiation can induce apoptosis and senescence, little is known about the effects of therapeutic irradiation concerning the commitment of mesenchymal stem cells to the os...

Astronauts on exploratory space missions will experience a complex environment that includes microgravity and radiation. While the deleterious effects of unloading on bone are well established, fewer studies have focused on the effects of radiation. Space radiation produces distinct biological damages which, up to now, little is known about the correlation between radiation exposure and bone tissue. In our study we used osteoblastic precursor cells to investigate the radiation...

Objectives: Children with congenital heart disease (CHD) have been found to have markedly low levels of physical activity (PA) compared to typically developing peers. It is well known that PA during the growing years has a beneficial effect on bone health with the most active children laying down more bone than their less active peers. If children with CHD are avoiding PA, current and future bone health may be compromised; however, very little is known of the bone health of ch...