Bone Abstracts

Biographical DetailsCatherine M Gordon, MD, MSc is a Professor of Pediatrics at the Alpert Medical School of Brown University and is Director of the Division of Adolescent Medicine at Hasbro Children’s Hospital. She is board-certified in adolescent medicine and pediatric endocrinology. She is on the Board of Directors for the International Society for Clinical Densitometry, and direc...

The childhood and adolescent years represent a critical period for bone acquisition. Extrinsic factors such as diet and physical activity represent modifiable variables that may have a significant impact on a young adult’s peak bone mass. This lecture will consider dietary supplementation with specific nutrients as a strategy to augment bone density during the childhood and teenage years. An overview will be provided, as well as data reviewed from supplementation trials i...

Vascular calcification is a ubiquitous pathology in the aged and diseased vasculature occurring at two sites in the vessel wall; in the intima in association with atherosclerosis and in the media in association with ageing, diabetes, and end-stage renal disease. Calcification at either site is associated with adverse cardiovascular outcomes including increased risk of myocardial infarction and arterial stiffness. Numerous studies have observed that vascular calcification and c...

Juvenile idiopathic arthritis (JIA) is associated with low bone mass, poor bone strength, and an increased fracture risk. Children with JIA enter adulthood with suboptimal bone mass. In children with JIA, fracturing of the 2nd metatarsal is common due to poor bone strength. Currently no gold standard measure exists for bone quality in the foot. A reproducible protocol is required to assess key bone outcomes at the 2nd metatarsal using pQCT.Objective: To ...

Gross motor development is positively associated with bone mineral density in teenagers and is thought to be mediated by lean mass. Age at walking is an accepted milestone in motor development, achieved by 50% of infants by 12 mo of age according to the WHO Motor Development Study.Objective: To examine if walking within 12 mo of age is related to bone mineral density (BMD) and if this relationship is mediated by lean mass.Methods: ...

We have shown that the bisphosphonate pamidronate (P) given to children <10d post-burn prevents resorptive bone loss and muscle protein breakdown. We have also shown in vitro that Ca modulates the inflammatory response by altering mononuclear cell chemokine production. We hypothesized that P affects muscle protein breakdown by altering cytokine or chemokine concentration directly or indirectly by lowering blood ionized (i) Ca. We retrospectively analysed biomarker...

The relationship between vitamin D status and lean mass accretion in young children is not well understood.Objective: To explore vitamin D status in relation to lean mass outcomes over 12 mo in children 2–8 years.Methods: This was a secondary analysis of trial data (clinicaltrials.gov: NCT02097160, NCT02387892) in Montreal, Canada. Children consumed their normal vitamin D intake for 6 mo (Apr–Oct 2014, n=39) and ...

In children, it is not well understood how bone mineral accretion is related to lean mass accretion and vitamin D status.Objective: To explore over 12 mo how bone parameters relate to lean mass and vitamin D metabolites in children 2–8 years.Methods: This was a secondary analysis of data from 2 trials (clinicaltrials.gov: NCT02097160, NCT02387892) in Montreal, Canada. Children consumed their normal diet without vitamin D suppl...

Background: Osteogenesis Imperfecta (OI) is most commonly caused by a defect in the genes which produce type 1 collagen. Features of OI include fractures, hypermobility and weakness. Severely affected children can present with deformities such as bowing of long bones and spinal curves. Mobility may be significantly impaired. The medical management of children with severe OI includes orthopaedic surgery and bisphosphonate treatment. Physiotherapy to promote function and partici...

Objective: Osteogenesis Imperfecta (OI) is most commonly caused by a defect in the genes which produce type 1 collagen. Features of OI include easy fracturing, short stature, hypermobility, weakness and fatigue. Our experience is that including a child with OI within a school or nursery environment can cause anxiety for both carers and staff. Questions often arise regarding how to promote participation whilst maintaining a child’s safety. Keeping up with the curriculum ca...