Bone Abstracts

Objectives: Special dual-energy X-ray absorptiometry (DXA) protocols permit quantification of bone mineralization, fat mass, and fat distribution in infants. Our objective was to evaluate the accuracy and precision of a multiscan acquisition protocol designed to allow for reflection and imputation analysis for regions with movement.Methods: The IMPAACT P1084s Study assesses bone and kidney safety of antiretrovirals used for PMTCT. Newborns received a spi...

Introduction: The patients with rheumatoid arthritis (RA) are less physically active than the general population. The aim of the study is to assess the effect of two exercise programs on the functional status of patients with early RA.Methods: Fifteen patients with early RA underwent ten high-intensity dynamic exercises using Enraf-Nonius gym for 45–60 min, including aerobic part (En-Cardio) and 18–20 muscle-strengthening exercises (En-Dynamic ...

Introduction: Physical exercises improve muscle strength, aerobic capacity and bone density in patients with rheumatoid arthritis (RA). However, some physicians fear to recommend the intensive exercises. The aim of the study is to compare the efficacy of two 6-month exercise programs in patients with early RA.Methods: Fifty-one patients with early RA were randomized into 3 groups. At hospital stage 15 patients underwent ten high-intensity dynamic exercis...

Objectives: In the modern society, all individuals are exposed throughout life to a variety of chemicals, which may contribute significantly to the human disease burden. Most of these chemicals are transferred to the fetus in-utero and to the infant via mother’s milk. Until recently, few studies have addressed effects of chemicals on the development of mineralized tissues following exposure during these early stages of life. In this experimental study, we analyse...

Introduction: The evidence for the effectiveness of early rehabilitation of patients with rheumatoid arthritis (RA) is scanty. The aim of the study is to evaluate the efficiency of rehabilitation program for patients with early RA.Methods: 34 study group patients with early RA underwent 6-month rehabilitation (hospital stage: 15-min local air cryotherapy (−;60 °C, Criojet Air C600) for hand, knee or ankle joints, 45-min therapeutic exercises u...

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Osteoporotic fractures are very common and represent an enormous unmet medical need. Our group has previously reported that addition of rTNF to the fracture site promotes fracture healing in C57/BL6 mice (Glass et al. PNAS 2011). Using a murine fracture model of endochondral healing, we observed that local addition of rTNF only accelerates fracture repair if administered within the first 24 h following injury. The optimal therapeutic dose is 1 ng. TNF is firs...

Two kinds of apatite powder were prepared separately from bovine bones originated from different geographical and ecological areas with different climates, in order to characterize and compare their components, hardness and structures by burning them and heat treating the bone ashes at 850 °C in an air furnace. The black ashes were converted to white and yellow–white powders. X-ray diffraction (XRD) analysis indicate that the white powder was carbonate–hydr...

Breastfeeding leads to marked trabecular bone loss as a result of high osteoclast- and osteocyte-mediated bone resorption. It has long been postulated that adequate dietary calcium intake prevents maternal bone loss, nevertheless, whether calcium supplement alleviates maternal bone mechanical property need to be investigated. Herein, we hypothesized that calcium supplement from natural sources could alleviate bone loss and improve mechanical property in lactating rats. During ...

Background: Elevated plasma homocysteine levels are a risk factor for osteoporotic fractures. Supplementation with vitamin B12/folic acid lowers homocysteine levels. This study aimed to determine whether vitamin B12/folic acid supplementation reduces osteoporotic fracture incidence in hyperhomocysteinemic elderly.Methods: B-PROOF is a double-blind, randomized, placebo-controlled trial including 2 919 participants aged ≧65 years with elevated homocyste...