Bone Abstracts

Background: Cabozantinib (CBZ) is a receptor tyrosine kinase inhibitor with activity against MET, VEGFR2, FLT3, c-KIT, and RET. Pre-clinical studies in models of prostate cancer bone metastasis demonstrated that CBZ treatment induced both a suppression of tumour growth and an alteration in bone remodelling, suggesting that both tumour and bone microenvironment represented potential CBZ targets. This is the first study exploring the potential direct activity of CBZ in bone usin...

Background: Osteogenesis Imperfecta is commonly due to dominant mutations in type I collagen genes, COL1A1 and COL1A2. Recessive forms, which are rarer, are caused instead by mutations in various genes coding for proteins involved in collagen post-translational modifications, folding and secretion. A novel disease locus, SERPINF1, coding for pigment-epithelium-derived-factor (PEDF), a likely key factor in bone deposition and remodelling, has been fou...

Background: Osteogenesis imperfecta (OI) is a group of hereditary disorders characterized by bone fragility and osteopaenia, with a broad spectrum of clinical severity. The majority of cases are dominantly inherited and due to mutations in type I collagen genes, whereas recessive forms are less frequent and attributable to mutations in different genes involved in collagen I post translational modifications and folding (prolyl-3-hydroxylase complex, SERPINH1, FKBP1...

Long-term bisphosphonate (BP) therapy can be complicated by atypical femoral fracture (AFF). A positive effect of teriparatide (TPTD) has been suggested.A woman (A, 81) with densitometric OP was put on alendronate (ALN) from 1997 until 2006, substituted by ibandronate (IBA), with an increase in FN-BMD of 6.6%. In August 2010, a fall from her standing height provoked a right transverse femoral fracture, which was operated. She was weaned from BP therapy. ...

Osteoporosis (OP) is characterised by low bone mass and microarchitectural deterioration of the bone tissue, leading to enhanced bone fragility and increased fracture risk. OP causes an imbalance in the cellular remodelling process thus inducing changes in the bone’s mineral and organic phases that are responsible for its strength and stiffness. The purpose of this study is to investigate the early effects of OP progression on the arrangement of bone tissue mineral phase ...

The aim of this study was to evaluate the effect of anabolic PTH on periodontal repair and mandibular bone defect in rats. Fenestration defects were created unilaterally of lower first molars in Wistar rats (n=32), and both periodontal ligament and cementum were removed. Animals were treated 3 times a week and then assigned to four groups (n=8): i) C14 – placebo administration for 14 days; ii) P14 – PTH administration for 14 days; iii) C21 – pl...

Background: Bone fragility and vascular calcifications are to the two main morbidities of the mineral and bone disorders associated with chronic kidney disease (CKD), resulting from a combination of abnormalities such as impaired GH axis, vitamin D deficiency, hyperparathyroidism, increased FGF23 levels, hypogonadism, denutrition and drug toxicity.Methods: In a single-centre ancillary study of the longitudinal prospective European 4C study (Cardiovascula...

Background: We have previously found in the chronic SKG mouse model of arthritis that long standing (5 and 8 months) inflammation directly leads to high collagen bone turnover, disorganization of the collagen network, disturbed bone microstructure and ultimately declining in bone biomechanical properties. Our main goal was to study the effects of the inflammatory process on the microarchitecture and mechanical properties of bone in the early stages of arthritis development.</p...

Background: Advancing maternal age at childbirth has been associated with a higher risk of pregnancy complications and with adverse short-term and long-term offspring health outcomes, but little is known about the effects of increasing maternal age on offspring bone acquisition.Objective: To investigate associations of maternal age at childbirth with offspring bone parameters in healthy men at the age of peak bone mass.Methods: We ...

Using a longitudinal observational study with two evaluations and a 1 year follow-up interval, we investigated the influence of everyday physical activity (PA) and skeletal geometry in bone mineral density (BMD) and bone mass distribution at the proximal femur (PF) in 96 girls and 81 boys (10–12 years). Whole body and left hip DXA scans were used to derive geometric measures of the pelvis (inter acetabular distance – IAD) and PF (abductor lever arm – ALA). BMD w...