Bone Abstracts

Introduction: Paget’s bone disease (PBD) is the second most prevalent metabolic bone disease. Most patients present with pain or fracture but many remain asymptomatic. Evidence suggests a significant reduction both in its prevalence and clinical severity. Recent papers described differences in clinical course and therapeutic options in the last 10–15 years.Objective: To characterize PBD differences between patients having been diagnosed before ...

Turn your challenges into opportunities through EU funding for research and innovation.The European Union encompasses several funding mechanisms to support research and innovation (R&I). One of its main instruments is Seventh Framework programme (FP7), established for the period 2007–2013, which is now approaching its end.The successor EU instrument, called Horizon 2020 (H2020), is currently under ...

Subchondral bone remodelling and osteophyte growth are widely recognised hallmarks of knee osteoarthritis (OA) although their contribution to disease is not fully understood. Murine models, with targeted genetic modifications, have become powerful tools for discovering disease pathophysiology. Our unpublished observations suggest that osteophyte formation is independent of cartilage loss thereby implying potentially independent molecular drivers. We have developed a novel imag...

It has long been known that osteoarthritis induces dramatic structural changes in subchondral bone. Studies on patients’ biopsies have also shown that the new sclerotic bone is hypomineralized and has decreased elastic modulus. Due to their amenability for genetic studies, murine models of OA are particularly important for drug target discovery. However, whilst osteosclerosis has been reported also in murine OA models, little is known about the compositional and mechanica...

Introduction: The loss of muscle mass (MM) is a serious problem which has been demonstrated in patients with rheumatoid arthritis. There are few studies about the loss of MM in patients with spondyloarthritis (Spa). In a recent case–control study in our department, the risk of sarcopenia in Spa patients was twice than in a healthy control group.Objective: To assess muscle mass index (MMI) in patients with axial Spa and to search a relation between s...

Introduction: Gorham disease (GD), also known as Gorham–Stout syndrome, massive osteolysis or disappearing bone disease, is a very rare disease characterized by spontaneous and progressive osteolysis of one or more bones. Its prognosis is highly variable and unpredictable, ranging from minimal disability to death, due to involvement of vital structures, such as the vertebral column and rib cage. Osteoclasts hyperactivity has been suggested as potential pathogenetic abnorm...

Introduction: Most studies to date have focus on the effect of exercise interventions on bone remodeling. Furthermore, inflammation has been associated with those critical for bone physiology and remodeling. However, investigations analyzing the relationship between objective physical activity and bone metabolism and inflammatory markers and the potential interactions with BMD and body composition in older men are limited, which is the aim of the present study.<p class="ab...

Osteoclasts are multinucleated giant cells derived from the monocyte/macrophage lineage in the presence of receptor activator of nuclear factor kappa-B ligand (RANKL) and colony-stimulating factor 1 (CSF1). The bone remodeling process in zebrafish is incompletely understood. Here we describe several methods to quantify bone formation and resorption using a zebrafish mutant that lacks functional colony stimulating factor 1a receptor (csf1ramh5/mh5). Mice deficient in...

Osteoclasts are myeloid-derived cells that degrade bone through the localized production of acid and proteases. The catabolic action of osteoclasts is counterbalanced by formation of new matrix by osteoblasts. In mammals, bone resorption and formation are coupled through crosstalk between osteoclasts and osteoblasts. Zebrafish are emerging as a valuable model to study bone biology, but how closely zebrafish osteoclast function parallels that of higher vertebrates is unknown. T...

Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are systemic, immune-mediated diseases. RA’s main targets are the peripheral joints while AS has the axial skeleton and enthesis as the principal affected areas. RA is characterized by bone erosions and impaired repair whilst AS is typified by bone overgrowth. The causes for these differences are not yet understood; however we hypothesize that AS patients’ monocytes receive reduced osteoclastogenic stimuli and...