Bone Abstracts

Osteogenesis Imperfecta (OI) is a brittle bone disease, characterized with reduced bone mass and bone fragility of different severity due to collagen type I defects. Patients suffer from recurrent spontaneous fractures starting in the early childhood or before birth.The main aim of the study was to relate time of the first fracture with COL1A1/2 mutations causing OI.Total number of 167 unrelated OI patients from the Osteog...

Osteogenesis Imperfecta (OI) is a rare congenital disorder of bone fragility. Majority of OI cases are caused by loss of function or missense pathogenic variants in the COL1A1/2 genes. In addition to fractures, patients suffer from different, mainly long bone, skeletal deformities. OI patients might develop chest deformities (pectus carinatum (PC) or excavatum (PE)) of different severity, which can tend to formation of cardiopulmonary complications. The main aim of current stu...

Objection: We compared T-scores of each femoral neck and trochanteric area in the neck fracture patients (NFP) and intertrochanteric fracture patients (IFP). Our hypothesis is that T-score of neck portion in NFP is lower than T-score of neck portion in IFP, and vice versa. We evaluate how FRAX probability is meaningful and sensitive in hip fracture patients.Meterials and methods: From April, 2003 to September, 2012, 18...

Introduction: A significant number of patient who have experienced previous surgical treatment for an osteoporotic hip fracture, experienced a subsequent hip fracture (SHF) on the opposite side. The incidence of asynchronous bilateral hip fractures is 1.7–14.8%. All hip fracture patients treated at five university hospitals in the Inchon and Bucheon area of Korea, were reviewed. The patients were divided into two groups, a group that had experienced subsequent hip fractur...

Objective: Individuals with type 2 diabetes have increased fracture risk despite higher bone mineral density (BMD). There are few studies regarding the effect of diabetes on bone mineral density and hip geometry in Asian population. The aim of this study was to examine the gender-specific influence of diabetes on BMD and hip geometry.Subjects and methods: A total of 1334 subjects (571 men and 763 women) ≥50 years of age were analyzed using data fro...

Background: Familial hypocalciuric hypercalcemia (FHH) is a rare autosomal dominant condition with an estimated prevalence of 1 in 78,000. The commonest cause of FHH is inactivating mutations of the calcium-sensing receptor (CASR) gene, with the rest mostly caused by missense mutations of the GNA11 and AP2S1 genes. FHH is characterized by persistent mild-to-moderate hypercalcemia, hypocalciuria with calcium-creatinine clearance ratio ⩽0.01. The disease runs a benign cou...

Introduction: The correlation between the occurrence of atypical femur fractures (AFFs) and prolonged bisphosphonate use has been reported in many studies. However, the incidence of AFFs is extremely low, which results in the lack of studies illuminating its treatment and clinical results so far. In this study, we aim to elucidate the clinical outcomes of bisphosphonate-associated AFFs and the clinical results depending on the bisphosphonate therapy period.<p class="abstex...

Inflammatory processes play a role in osteoclastogenesis. C-reactive protein (CRP), an acute phase reactant that reflects different degree of inflammation. More recently, accumulating evidence suggest that CRP is not only an inflammatory marker but also direct cause of diseases. Therefore, we examined the direct effects of CRP on osteoclast formation using RAW 264.7 cells. CRP significantly inhibited RANKL-induced TRAP-positive multinucleated cell formation in RAW 264.7 cell c...

Background and objectives: The association between excess calcium intake and cardiovascular mortality has been reported, but the association has not yet been explored according to serum vitamin D status. Thus, we investigated the relation of dietary calcium intake and Framingham risk score (FRS) according to serum 25-hydroxyvitamin D (25(OH)D) status.Methods: A total of 7809 subjects (3452 males and 4357 female) aged over 40 years from the data of the Ko...

Introduction: Hypertrophy of ligamentum flavum (LF) induces narrowing of spinal canal which develops neurogenic claudication. Several mechanisms of LF hypertrophy have been suggested. Among them inflammatory cytokine play a crucial role in LF hypertrophy by increasing collagen synthesis. Cyclooxygenase-2 (COX-2) pathway shares inflammatory reaction from infection and arthritis. Selective COX-2 inhibitor (COX-2si) might modulates collagen synthesis via suppressing inflammatory ...