Bone Abstracts

Introduction: Fibrous dysplasia (FD) of bone is a benign, non-inheritable disease characterized by bone pain, bone deformities and fractures. Its prevalence is ~1 in 30 000 individuals and diagnosis is based on the clinical and radiologic findings and is confirmed by biopsy. Yet, in some cases biopsy is not applicable.Case report: A young woman presented to our outpatient clinic with a history of pain localized at the distal half of the left tibia that h...

Objective: The objective of this observational cross-sectional study is to identify heel bone properties, specifically broadband ultrasound attenuation (BUA), speed of sound (SOS) and stiffness index (SI), in healthy Greek women, as well the relation of these parameters with age, serum 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH).Material and Methods: A population of 738 community dwelling women was recruited at the health promotion events...

Introduction: Pregnancy- and lactation-associated osteoporosis (PLO) is an uncommon disease. The majority of cases are seen in the third trimester or early post-partum in the primagravid women and the prominent clinical feature of PLO is the severe and prolonged back pain and height loss. To date the prevalence and the aetiology of this disorder are unclear and there are no guidelines for its treatment.Case report: We report the outcomes of teri...

Background: Short stature is a very common reason for referral to a pediatric endocrinologist. Endocrine and non endocrine causes are involved. Short stature can be classified as symmetrical or non-symmetrical. Numerous monogenic causes of growth disorders have been identified.Presenting problem: To present two brothers with familial spondyloepiphyseal dysplasia presenting with short stature and very low growth velocity starting at the age of 8 years. Th...

Introduction: Osteoporosis and fractures are multifactorial events. Muscle weakness and changes in bone density are of special importance. The aim of this study was to determine wether clinically applicable physical tests could be used to identify the relation between physical performance and fractures.Methods: Data of 179 community dwelling female patients (mean age 74±5.4 years) suffering osteoporosis were retrospectively investigated. Peripheral ...

Introduction: Autosomal dominant hypophosphatemic rickets (ADHR) is a rare form of inherited isolated renal phosphate wasting with two distinct clinical phenotypes; early-onset and late-onset. Late-onset ADHR is characterized by normal phosphate levels and growth during childhood, followed by osteomalacia with bone pain, pseudofractures and weakness in adolescence or adulthood, but with no lower extremity deformities. Most of the late-onset ADHR patients are women and pregnanc...

Osteosarcoma is the most common primary bone-derived tumor. However, the pathogenic molecular mechanism(s) underpinning osteosarcoma development and metastasis remain elusive. The polycystins PC1 (polycystin-1; encoded by PKD1) and PC2 (polycystin-2) are central players in mechanotransduction, a process that can influence all steps of the invasion/metastasis cascade. Recent studies from our laboratory provided, for the first time, a direct link between mechanosensing polycysti...

Background: Current studies concerning the incidence of vertebral fractures are rare. Knowledge about age and sex dependency of these fractures could help focussing therapeutic decisions. Therefore, we performed a prospective study in order to find a reliable incidence of clinical vertebral fractures in an adult population.Methods: Included were all patients with radiologic confirmed clinical vertebral fractures, which occurred in the adult population (a...

Osteoporosis is a frequent disease leading to an increased risk of fractures caused by a systemic impairment of bone mass, strength, and microarchitecture. Given the emerging role of the Wnt signaling pathway in bone biology, we focused on the function of the important Wnt inhibitor dickkopf-1 (Dkk-1) and examined how the deletion of Dkk-1 solely in osteoblasts or osteocytes influences bone homeostasis. Therefore, we used the Cre-LoxP recombination system and crossed Dkk-1-flo...