Bone Abstracts

Objectives: To define the role of bone morphogenetic proteins (BMP) in human osteochondromas. The expression of bone morphogenetic proteins and their corresponding receptors has not been clarified in osteochondromas. We determined immunohistochemically the localization and distribution of bone morphogenetic proteins 2, 4, 6 and 7, bone morphogenetic protein receptor types 1A, 1B and 2 and the functional effectors phosphorylated Smad proteins 1, 5 and 8 in the cartilaginous cap...

see P85....

Matrix vesicles (MVs) play a key role in bone mineralization. These nano-sized vesicles bud from apical microvilli of osteoblasts and accumulate in osteoid, and initial hydroxyapatite crystals form within these vesicles. MVs appear to share a common feature with exosomes. Recent studies have demonstrated that exosomes include microRNAs (miRNAs) as mediators of intercellular communication. We purified MVs from MC3T3-E1 cell cultures by ultracentrifugation and found approximatel...