Bone Abstracts

Hypophosphatasia is an autosomal recessive rare metabolic disorder characterized by decreased bone mineralization. It can be seen in infancy, childhood or adolescence. Disease occurs due to the loss of non-specific alkaline phosphatase activity in liver, kidney and bones. There is no specific treatment. Two infants with growth retardation and failure to thrive diagnosed as infantile hypophosphatasia are presented.Our cases had abnormalities including sho...

Introduction: Treatment in thyroid function disorders, which lead to clinical hypothyroidism, is replacement with levothyroxine. We aimed to investigate the effect of long-term levothyroxine therapy on vitamin D metabolism and bone mineral density in children.Materials and methods: Twenty-seven children with hypothyroidism receiving levothyroxine therapy (M/F: 13/14, mean age, 12.1±0.7 years) and 21 healthy controls (M/F: 13/8, mean age, 11.8±0...

Osteoarthritis (OA) is a chronic, slowly progressive disease of the joints and is one of the most common causes of pain and disability in middle-aged and older people. The etiology and pathogenesis underlying this disease are poorly understood. Progranulin (PGRN), a secreted glycoprotein expressed in many cell types, has been linked to wide variety of biological processes. In recent years, increasing evidence suggests that PRGN stimulates chondrocyte proliferation and is consi...

The pathogenesis of tendinopathy remains unclear. Small integrin-binding ligand N-linked glycoproteins, a family of non-collagenous proteins including osteopontin (OPN) and bone sialoprotein (BSP), were initially thought to be limited to mineralized tissue but recent studies showed that they are more widely distributed and are expressed in nonmineralized tissues. Musculoskeletal tissue cells are categorized as the same functional unit developed from the mesenchymal stem cells....

Pathologist Christian Georg Schmorl described a specific type of vertebral lesion, which is now known as Schmorl’s node. A Schmorl’s node or intradiscal herniation is herniation of nucleus pulposus through the cartilaginous and bony end plate into the body of an adjacent vertebra. Schmorl nodes are seen primarily in the thoracolumbar spines in an elderly population. Schmorl nodes are associated with moderate but not advanced degenerative changes. An 11-year-male pres...