Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp131 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2013

Effects of zoledronic acid on hormone levels in premenopausal women with breast cancer receiving neoadjuvant or adjuvant chemotherapy and endocrine therapy: Probone II Study

Hadji Peyman , Kauka Anette , Bauer Thomas , Ziller May , Birkholz Katrin , Baier Monika , Muth Mathias , Kann Peter

Introduction: Loss in bone mineral density may occur soon after initiation of adjuvant therapy for hormone-receptor-positive (HR+), breast cancer (BC) and correlates with changes in hormone levels. Adding zoledronic acid (ZOL) to adjuvant treatment for BC can preserve/improve bone mineral density and delay disease recurrence; however, effects of ZOL on endocrine hormone levels are currently unclear.Methods: Probone II assessed the course of endocrine hor...

ba0001pp161 | Cancer and bone: basic, translational and clinical | ECTS2013

Effect of zoledronic acid on bone mineral density in premenopausal women receiving neoadjuvant or adjuvant therapies for breast cancer: the ProBONE II Study

Hadji Peyman , Kauka Anette , Bauer Thomas , Birkholz Katrin , Baier Monika , Muth Mathias Muth , Ziller May

Introduction: Bone mineral density (BMD) evaluations have shown that adjuvant chemotherapy or endocrine therapy (ET) for early breast cancer (BC) is associated with accelerated BMD loss and increased fracture risk. In recent studies, zoledronic acid (ZOL) increased BMD in premenopausal and postmenopausal women with BC, and improved disease-free survival in some patient subsets compared with no ZOL. The purpose of the current study was to investigate the effect of adjuvant trea...

ba0001oc5.1 | Treatment of osteoporosis | ECTS2013

A Three-year randomized sham-controlled trial of low magnitude mechanical stimulation in an elderly sample: the ‘VIBES' trial

Kiel Douglas , Hannan Marian , Sisson Emily , Bouxsein Mary , Barton Bruce , Dewkett Dawn , Magaziner Jay , Zimmerman Sheryl , Shane Elizabeth , Leary Elizabeth Teng , Carroll Danette , Allaire Brett , Lang Thomas , Rubin Clinton

Non-pharmacologic approaches to preserve or increase BMD include whole body vibration (WBV). A meta-analysis and one-year randomized trial concluded that WBV has no effect on BMD in older women; however, previous trials were relatively brief and did not include a sham control group. Therefore, we conducted the Vibration to Improve Bone in Elderly Subjects (‘VIBES’) trial, a randomized, sham-controlled trial of 10 min of daily WBV (0.3 g at 30 Hz) in seniors recruited...

ba0004p79 | (1) | ICCBH2015

Nonbacterial osteitis: Is there any mismatch in the pathophysiology of osteoblasts or osteoclasts?

Singh Delila , Pozza Susanne Bechtold-Dalla , Gesell Isabella Susanne , Schmidt Heinrich , Jansson Annette

The aim of the study is to determine whether there is an imbalance between bone formation and bone resorption in nonbacterial osteitis. The osteoclast inhibitor pamidronate has been successfully used in nonbacterial osteitis. It is assumed, that there is any mismatch in the pathophysiology of osteoblasts or osteoclasts. Until now, we have no known publications on bone metabolism in nonbacterial osteitis. We chose osteoprotegerin (OP) and alkaline phosphatase (AP) as markers of...

ba0006oc16 | (1) | ICCBH2017

Pediatric hypophosphatasia – a retrospective single-center chart review of 50 children

Vogt Marius , Girschick Hermann Josef , Holl-Wieden Annette , Seefried Lothar , Jakob Franz , Hofmann Christine

Objectives: Hypophosphatasia (HPP) is a rare, inherited metabolic disorder caused by loss-of-function mutations in the ALPL gene that encodes the tissue-nonspecific alkaline phosphatase TNAP (ORPHA 436). Its clinical presentation is highly heterogeneous with a remarkably wide-ranging severity. HPP affects patients of all age. Therefor diagnosis is often difficult and delayed. To improve the understanding of HPP in children and in order to shorten the diagnostic time span in th...

ba0006p184 | (1) | ICCBH2017

Physical activity and health-related quality of life in patients with chronic non-bacterial osteomyelitis – pilot and model project in a rare inflammatory bone disease

Nentwich Julia , Holl-Wieden Annette , Morbach Henner , Girschick Hermann Josef , Ruf Katharina , Hebestreit Helge , Hofmann Christine

Objectives: Chronic non-bacterial osteomyelitis (CNO) is an inflammatory, non-bacterial disorder of the skeletal system of yet unknown etiology (ORPHA 324964). CNO predominantly affects the metaphyses of long bones, but lesions can occur at any sites of the skeleton. Patients present with local bone pain and inflammation and - to our experience - often suffer from functional impairment with significant disabilities of daily life. The objective of this study was to assess physi...

ba0001pp111 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2013

The effect of gastric bypass treatment for obesity on hormones related to bone re-modeling and intestinal growth

Hartmann Bolette , Vestergaard Henrik , Bonfils Peter , Hansen Marie , Albrechtsen Nicolai , Eskildsen Peter , Floyd Andrea , Svenningsen Annette Lykke , Holst Jens Juul

Aim: The aim of the study was to investigate the relationship between gut hormones and bone re-modeling and intestinal growth by measuring meal stimulated changes in hormones and bone markers in blood samples collected from patients before and after gastric bypass (GBP).Methods: Eighteen patients (12 females and 6 males) were included in the study, approved by the Municipal Ethical Committee of Copenhagen. All subjects were studied before surgery (~2 wee...

ba0001pp215 | Cell biology: osteoclasts and bone resorption | ECTS2013

The F-actin modulator SWAP-70 is required for proper podosome dynamics in osteoclasts

Roscher Anne , Glosmann Martin , Reinhold G Erben , Lutter Anne-Helen , Chopin Michael , Lorenz C Hofbauer , Jessberger Rolf , Garbe Annette

Bone remodeling is a crucial process to maintain a healthy bone structure in order to avoid diseases like osteoporosis or osteopetrosis. Osteoclasts contribute to this process by resorbing old and brittle bone allowing osteoblasts to renew the bone substance. During resorption osteoclasts rearrange their actin cytoskeleton by forming an F-actin ring generating a resorptive cavity on the bone surface. Recently, we reported that the F-actin binding protein SWAP-70 regulates oste...