Bone Abstracts

Oftenly, the question arises whether anti-osteoporotic drugs should be prescribed in glucocorticoid-treated premenopausal women. On the one hand, there are strong arguments to prescribe these drugs, when these patients are treated with high dose glucocorticoïds, and suffer from diseases that have a negative effect on bone, for instance SLE.On the other hand, the absolute fracture risk is low, related to their young age, and finally, in women with ch...

Objective: This multi-objective prospective observational study is intended to examine treatment patterns, occurrence of gastrointestinal (GI) complications and clinical and health outcomes in post-menopausal women with osteoporosis (OP) in Europe and Canada. This abstract presents the baseline results of the treated population.Materials and methods: Post-menopausal osteoporotic women currently on treatment completed surveys intended to measure the incid...

Objective: This multi-objective prospective study (MUSIC-OS) is intended to examine treatment patterns, occurrence of gastrointestinal (GI) complications and clinical and health outcomes in post-menopausal osteoporotic (OP) women in Europe and Canada. Surveys were administered to both physicians and patients as part of the MUSIC-OS study to document reasons for undertreatment in OP from both physician and patient perspectives.Materials and methods: A phy...

The ECTS and IOF have recently constructed a framework for the development of national guidelines for the management of glucocorticoid-induced osteoporosis in men and women aged 18 years and over in whom oral glucocorticoid therapy is considered for three months or longer. These review the epidemiology of GIO; assessment of risk utilises a fracture probability-based approach and intervention thresholds are based on 10 year probabilities using FRAX. National guidelines derived ...

Therapeutic glucocorticoids are still widely used for their anti-inflammatory effects. There are however significant side effects associated with their use. These include effects on bone leading to osteoporosis and fracture but also on muscle (increasing risk of falls) and systemic fuel metabolism (leading to diabetes and increased cardiovascular risk). Research over many decades has tried to develop agents which retain the anti-inflammatory effects of glucocorticoids but have...

The fundamental purpose of osteoporosis treatment is to reduce the risk of fracture. There is no validated quantitative marker that monitors risk reduction in the individual patient; available treatments are effective, but reduce fracture incidence only by 20–60%, and it is to be expected, therefore, that fractures will arise during treatment. The aim of treat-to-target strategies is to simplify management and ultimately reduce organ damage and improve clinical outcomes. ...

The Rab family GTPases Rab27a and Rab27b play an important role in the trafficking of lysosome-related organelles in specialised cells, such as melanocytes. Since secretory lysosomes, also considered a lysosome-related organelle, are important for osteoclast and osteoblast function, we hypothesised that Rab27 plays a role in bone physiology. In support of this, a recent study demonstrated impaired transport of RANK ligand to the plasma membrane in osteoblasts from mice lacking...

see PP380....

The origin of the recent levelling-off in hip-fracture incidence in several settings is unknown.Methods: Using Danish national inpatient data for individuals aged ≥50 years during 1980–2010, we examined annual number and incidence of hip fractures and age, period, and cohort effects by log-likelihood estimates in Poisson regression models. Age adjustment was done by direct standardization, time-trend analysis by linear regression, and identifi...

Objective: The reasons for the recent decrease in hip fracture rates remain unclear. While current antiosteoporosis efforts are important also factors earlier in life seem essential and we examined age-period-cohort (APC) effects in hip fracture incidence in the Sweden (SE) and Denmark (DK).Material and Methods: We studied the entire populations aged ≧50 years from 1987 to 2010 in SE and DK and ascertained acute hip fractures in nationwide discharge r...