Bone Abstracts

Recent studies indicate a potential importance of the antioxidant α-tocopherol for bone and the development of sarcopenia. No longitudinal clinical fracture studies have been performed. We aimed to determine whether α-tocopherol intake or serum concentrations are associated with fracture risk in older women and men. We used data from two community-based cohorts, the Swedish Mammography Cohort (SMC; 61 433 women) and the Uppsala Longitudinal Study of Adult Men (ULSAM;...

Bone damage is one of the main unfavourable health effects of chronic exposure to cadmium (Cd). This heavy metal stimulates osteoclastic bone resorption and inhibits osteoblastic bone formation resulting in decreased bone mineralization and as a result weakening of the bone biomechanical properties. Recently, using a rat model of chronic human exposure to cadmium, we have revealed that even low exposure to this metal may increase bone vulnerability to fracture. Taking into acc...

Cadmium is characterized by oxidative properties and this heavy metal-induced oxidative stress has been recognized to be involved in its injurious impact on the skeleton. Oxidative/reductive processes are an integral component of bone remodeling; however, destroying of the bone tissue oxidative/antioxidative status with excessive production and accumulation of reactive oxygen species has detrimental impact on bone metabolism. Thus, the aim of this study was to investigate whet...

Primary hyperparathyroidism is extremely rare in childhood and adolescence. Here we report a clinical case of a 15-year-3-month-old boy who began 2 years before with pain in his knees, genu varum, and fatigue. Physical examination showed severe genu valgum with an inter-malleolar distance of more than 30 cm. Biochemical tests showed hypercalcemia (12.2 mg/dl), hypophosphatemia (2.3 mg/ dl), hypercalciuria (6.4 mg/kg per day), high alkaline phosphatase (2812 IU/l), low 25-hydro...

Introduction: Research on biomaterials for bone regeneration generates a plethora of new biomaterials requiring evaluation with reliable and comparable methods of biocompatibility and functionality for clinical translation. To reduce the burden of in vivo assessment, there is a need for refined in vitro assays that are predictive of in vivo outcomes. This retrospective study correlated in vitro results with in vivo outcomes observed...

There is a growing evidence of the association between HIV infection and fracture risk. Independently of its cause (antiretroviral therapy (ART) or HIV), what remains most important is a prompt diagnosis. Although densitometry is the gold standard, sometimes this technique is not as accurate as necessary in clinical practice. A new validated tool for early and more accurate diagnosis is presented.MethodsIn a HIV group of patients, ...