Bone Abstracts

ACH (achondroplasia) is one of the most common skeletal dysplasias with severe short stature caused by gain-of-function mutations in the FGFR3 gene. Foramen magnum stenosis is a serious neurological complication of ACH. Downregulation of the FGFR3 signaling is a radical therapeutic strategy for the disease. We previously demonstrated that meclozine, an over-the-counter drug for motion sickness, inhibited elevated FGFR3 signaling in chondrocytic cell lines. In the present study...

Objective: Little is known about the effects of muscle strength and muscle mass on bone health in children and adolescents. We examined the relative impact of muscle strength and muscle mass on bone mineral density in Japanese adolescents.Methods: Subjects were 236 adolescents aged 15–18 years in August 2010 and August 2013 who were enrolled in the Kitakata Kids Health Study in Japan. Cross-sectional data including appendicular skeletal muscle mass ...