Bone Abstracts

Osteosarcoma is the most common primary bone-derived tumor. However, the pathogenic molecular mechanism(s) underpinning osteosarcoma development and metastasis remain elusive. The polycystins PC1 (polycystin-1; encoded by PKD1) and PC2 (polycystin-2) are central players in mechanotransduction, a process that can influence all steps of the invasion/metastasis cascade. Recent studies from our laboratory provided, for the first time, a direct link between mechanosensing polycysti...

Objective: The objective of this observational cross-sectional study is to identify heel bone properties, specifically broadband ultrasound attenuation (BUA), speed of sound (SOS) and stiffness index (SI), in healthy Greek women, as well the relation of these parameters with age, serum 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH).Material and Methods: A population of 738 community dwelling women was recruited at the health promotion events...

: Inadequately treated hypophosphataemic rickets (HR) in 14-year-old boy: a case reportBackground: HR is a rare cause of short stature associated with limb deformities.Objective: To report the clinical, laboratory and radiologic features of HR in a 14-year-old boy.Presenting problem: We present the case of the 14-year-old boy, with short stature and deformities of extremities, who complained for limb pain and...

Introduction: Oral health problems are common in patients with primary metabolic bone diseases. We aimed to investigate the oral health of patients with primary osteoporosis and genetic mineralization disorders and correlate the oral health findings with clinical, imaging and laboratory parameters.Patients and methods: Twenty nine patients 2.8y-17y (15 males, 22 prepubertal) with primary metabolic bone diseases underwent a comprehensive dental examinatio...

Background: Cleidocranial dysplasia (CCD) is an ultra-rare (1/1,000,000) genetic bone disorder, characterized by hypoplastic or aplastic clavicles, persistence of wide-open fontanelles and multiple dental abnormalities. It is caused by mutations in the RUNX2 gene, involved in the differentiation of osteoblasts.Presenting Problem: A case of a 13 year-old girl with a clinical diagnosis of CCD is reported. Her clavicles were hypoplastic and her shoulders co...

ExFOS is a multicenter, prospective, observational study to evaluate fracture outcomes, back pain, compliance and health-related quality of life in female and male patients with osteoporosis treated with teriparatide [rhPTH(1–34)] (Forsteo)for 18 to 24 months. Post-treatment follow-up will last for at least 18 months. Patients were enrolled in Croatia, Denmark, France, Greece, Italy, Norway, Slovenia, and Sweden. The study design was non-interventional and all consenting ...