Bone Abstracts

Objective: The purpose of this study was to verify the influence of age, body mass and stature on the functionality level of children with Osteogenesis Imperfecta (OI). METHODS: Thirty-eight children (8.21±4.26 years, 19 girls and 52.6% OI type III) were evaluated during their hospitalization for Pamidronate intravenous infusion in the Brazilian Midwest reference hospital for OI treatment (University Hospital of Brasília). Body weight and stature were measured and capability and performance of functional activities were evaluated in three content domains: self-care, mobility and social function autonomy through the Pediatric Evaluation of Disability Inventory (PEDI). All data analyses were performed using SPSS program (SPSS Inc., USA). Two types of multivariate linear regression analysis - hierarchical and stepwise - were performed. The hierarchical method examined the weight of each variable accounting on PEDI score. To examine if a combination of predictors would explain more variance in the PEDI score, the variables entered in a multivariate stepwise analysis. The level of significance adopted was 0.05. RESULTS: The anthropometric values showed that 58.3 were classified as normal weight, 27.8% were overweight, 8.3% were obese and 5.6% presented severe obesity. The hierarchical regression results presented that height explained 66% of variance in the PEDI (B=1.28, SE B=0.25, β=1.4, P=0.000), and including weight in the second step the model explained 70% of the PEDI score (B=−1.15, SE B=0.49, β=−0.63, P=0.026). The age was not significant as a variable to explain PEDI when it was included in the model. Also, the stepwise regression retained only height and weight as predictive variables. CONCLUSION: Height and weight are more predictive variables of disability than age in children with Osteogenesis Imperfecta.

Disclosure: The authors declared no competing interests.