Bone Abstracts

The circadian clock network is an evolutionally conserved system by which organisms adapt their metabolic activities to the environmental inputs including the availability of nutrients. The master pacemaker of circadian clock system is located in the suprachiasmatic nucleus (SCN) and is well known to play pivotal roles in metabolic regulations including skeletal and mineral metabolisms. In addition to the central pacemaker, peripheral tissues also possess its own circadian system and synchronize with central clock system through hormonal and neuronal signals. Importantly, peripheral circadian system is entrained by external cues such as food availability independent of central regulation. The organisms take advantage of this system to allow for the predictable time-of-day dependent utilization of ingested nutrients by optimizing the metabolic processes of nutrients in peripheral tissues. These findings suggest that circadian regulation of nutrients metabolism is a nodal point connecting nutrient and tissue metabolism. Among the nutrients, calcium and phosphate are the critical components for skeletal metabolism and circulating calcium/phosphate levels have been shown to have circadian profiles in humans, suggesting that mineral metabolism is under the regulation of circadian clock system and disruption of which may affect skeletal homeostasis; however, this has not been well investigated so far. In this talk, I would like to present the current findings how calcium and phosphate metabolism is regulated by circadian clock network and its influences on bone metabolism.

Disclosure: The authors declared no competing interests.

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