ICCBH2017 Poster Presentations (1) (209 abstracts)
Physical activity is negatively correlated with circulating sclerostin in 6--12 year-old children
Theodoros Stampoulis 1 , Diamanda Leontsini 1 , Alexandra Avloniti 1 , Dimitrios Draganidis 2 , Konstantinos Papanikolaou 2 , Athanasios Chatzinikolaou 1 , Maria Michalopoulou 1 , Dimitris Vlachopoulos 5 , Luis Gracia-Marco 5, , Konstantinos Makris 3 , Symeon Tournis 4 , Athanasios Jamurtas 2 , Ioannis Fatouros 2 & Antonis Kambas 1
1Democritus University of Thrace, Komotini, Greece; 2University of Thessaly, Trikala, Greece; 3KAT General Hospital, Athens, Greece; 4University of Athens, Athens, Greece; 5University of Exeter, Exeter, UK; 6University of Zaragoza, Zaragoza, Spain.
Objectives: Bone mass development through childhood is very important for osteoporosis prevention during adulthood. Physical activity (PA) and/or exercise can influence positively bone matrix and its contents in pre-adolescents Sclerostin, a glycoprotein produced by osteocytes, promotes osteoclastic activity and it is associated with reduced bone formation. The purpose of this study was to describe the relationship between PA and sclerostin levels in pre-adolescent boys and girls aged 6–12 years.
Methods: A cross-sectional design with 206 children (6–8 years: n=101; 9–12 years: n=105) was employed. The sample included both boys (n=108) and girls (n=98). Maturity was examined with Tanner stages of sexual maturity. Participants had their body mass, body height, tibia length and hip and waist circumference measured. Dual energy X-ray absorptiometry (DEXA) was used to measure body composition as well as body mineral density (BMD) and content (BMC) at hip and lumbar spine. Daily physical activity was measured using accelerometry (for 7 days). Power of lower limb muscles and cardiovascular endurance were determined using long jump and shuttle run testing, respectively. Blood samples were collected at rest to measure serum sclerostin. Comparisons between PA (low, moderate and vigorous), sex (boys and girls) and age (6–8 vs 9–12 years) groups were performed using analysis of variance while a partial correlational analysis (adjusted for BMI) was used to correlate PA and serum sclerostin concentration.
Results: Serum sclerostin was lower in children with moderate and vigorous higher daily PA compared to those with low PA independent of age. Boys had higher sclerostin levels than girls in the low but not in moderate and high PA groups. Older children (9–12 years) demonstrated higher sclerostin levels than younger children (6–8 years) independent of PA level and sex. Sclerostin was negatively correlated with PA (−0.58, P<0.05), muscle power (−0.61, P<0.05) and endurance (−0.52, P<0.05).
Conclusion: The results of this study indicate that serum sclerostin are affected by PA level, performance, age and sex during childhood suggesting that increased PA may promote osteogenic activity probably through a down regulation of sclerostin.
Disclosure: The authors declared no competing interests.
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