ICCBH2017 Poster Presentations (1) (209 abstracts)
Age at onset of walking affects bone mineral content in early childhood
Saara Valkama , Heli Viljakainen , Elisa Holmlund-Suila , Jenni Rosendahl , Helena Hauta-alus , Maria Enlund-Cerullo , Otto Helve , Sture Andersson & Outi Mäkitie
Children’s Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Objectives: The aim of this study was to evaluate the association between the age at onset of walking and bone mineral content (BMC) in healthy 2-year-old children participating in the Vitamin D in Infants Trial (VIDI).
Methods: Altogether 253 children (120 girls, 133 boys) with a daily vitamin D3 intake of 10 μg and a sufficient serum 25-hydroxyvitamin D (25-OHD) concentration (>50 nmol/l) were included in the analysis. BMC was measured at 20% of the distal length of the left tibia with a peripheral quantitative computed tomography (pQCT) (Stratec Medizintechnik). Scans were analysed using the loop function with a threshold of 180 and 400 mg/cm3 for total and cortical bone, respectively. During the study visit at 2 years, data on onset of walking was collected retrospectively with a questionnaire. Anthropometric measurements and a blood sample for 25-OHD concentration were obtained.
Results: Serum 25-OHD ranged between 50.1 and 153.5 nmol/l. The age at onset of walking did not differ between sexes (P=0.844) but boys were heavier than girls at 2 years (mean 12.9 vs.12.0 kg, P<0.001). BMC was higher in boys than girls (mean 56.5 vs. 52.2 mg/mm, P<0.001). Weight associated with BMC in boys (r=0.475, P<0.001) and girls (r=0.649, P<0.001). Serum 25-OHD and BMC did not associate either in boys or girls (P=0.543 and P=0.704). In a linear model, adjusted with weight and 25-OHD, the age at onset of walking associated with BMC in both sexes (P=0.002 and P=0.046) (Table 1).
Conclusions: These findings indicate that the onset of walking and weight are more important determinants of bone mineral content than serum 25-OHD in vitamin D sufficient healthy toddlers.
| BOYS | GIRLS | |||||
| Adjusted | CI 95% | P | Adjusted | CI 95% | P | |
| Weight (kg) | 3.047 | 2.109; 3.985 | <0.001 | 3.829 | 3.011; 4.647 | <0.001 |
| Walking age (months) | −1.153 | −1.892; −0.415 | 0.002 | −0.553 | −1.094; −0.011 | 0.046 |
| Serum 25-OHD | 0.020 | −0.045; 0.085 | 0.543 | 0.010 | −0.043; 0.064 | 0.704 |
Disclosure: The authors declared no competing interests.
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