ECTS2016 Poster Presentations Other diseases of bone and mineral metabolism (52 abstracts)
Cortical density is lower in patients with Graves' disease compared to healthy controls
Sofie Malmstroem 1 , Diana Grove-Laugesen 1 , Eva Ebbehøj 1 , Klavs Würgler Hansen 2 , Torquil Watt 3 & Lars Rejnmark 1
1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark; 2Medical Department, Regional Hospital Silkeborg, Silkeborg, Denmark; 3Department of Medical Endocrinology, Rigshospitalet, Copenhagen, Denmark.
Objective: Hyperthyroidism leads to reduced mineral bone density and is associated with increased risk of fracture. Whether the effect of increased bone turnover is identical in cortical and trabecular bone in unknown. Using a cross sectional design we aimed to investigate which bone compartment is affected.
Methods: Nineteen newly diagnosed patients with Graves’ disease (GD) and nineteen euthyroid controls matched on age, gender and menopausal status were scanned using a high-resolution pQCT scanner (XtremeCT, Scanco Medical AG, Bruüttisellen, Switzerland). Volumetric bone mineral density, cortical and trabecular architecture, and strength as estimated by finite element analysis were measured in the distal radius and tibia.
Result summary: 1Mann Whitney U-test for difference between groups.
2Median with interquartile range.
Age was similar between groups with a mean age of 39 in patients and 38 in controls. No significant difference in trabecula architecture or strength was found in patients compared to controls.
Conclusion: Loss of bone density at distal sites in patients with GD seems caused by reduced cortical density.
Whether this is the major cause for the increased risk of fractures in GD needs further explorations.
Ethical approval was obtained from all required authorities.
| Cortical bone density 2 (mg HA/cm3) | P1 | Cortical thickness2 (mm) | P1 | ||
| Radius | Controls | 840 (804–875) | 0.037 | 0.60 (0.55–0.66) | 0.085 |
| Patients | 883 (851–929) | 0.77 (0.60–0.93) | |||
| Tibia | Controls | 871 (833–895) | 0.002 | 1.05 (0.91–1.29) | 0.065 |
| Patients | 903 (881–927) | 1.22 (1.11–1.35) |
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