ECTS2016 Poster Presentations Other diseases of bone and mineral metabolism (52 abstracts)
Impaired quality of life and muscle function in patients with hypoparathyroidism/hypothyroidism compared with only hypothyroidism and controls
Tanja Sikjaer 1 , Emil Moser 1 , Lars Rolighed 2 , Line Underbjerg 1 , Lise Bislev 1 , Leif Mosekilde 1 & Lars Rejnmark 1
1Department of Internal Medicine and Endocrinology, MEA, 2Department of Surgery P, Aarhus University Hospital, Aarhus, Denmark.
Total thyroidectomy causes postsurgical hypothyroidism (HypoT). Besides HypoT, patients may also develop hypoparathyroidism (HypoPT).
The aim of the study was to assess Quality of Life (QoL), muscle function, and bone indices in patients with postsurgical hypothyroidism and hypoparathyroidism (HypoT+PT) as compared to patients with postsurgical HypoT and healthy controls.
Age and gender matched patients on treatment for HypoT+PT and HypoT were recruited from our out-patient clinic. Matched healthy controls were recruited from the general background population.
Compared with controls, HypoT was associated with a significantly lower mental summary score, whereas patients with HypoT+PT had a significantly lower physical summary score (Short Form 36 Health Survey questionnaire version 2). Moreover, the physical component score was significantly lower in patients with HypoT+PT compared with HypoT. WHO-5 well-being index was significantly lower in both groups of patients compared with controls, but did not differ between groups of patients. Compared with controls, muscle strength and maximal force production was significantly reduced in HypoT+PT, but not in HypoT. In HypoT+PT, the time spend on the Timed Up and Go test and the Repeated Chair Stands test were significantly longer than in the HypoT- and the control-group. Biochemical markers of bone turnover were decreased in HypoT+PT and bone mineral density was increased at the lumbar spine. However, trabecular bone score (TBS) did not differ between groups.
Postsurgical HypoT+PT is associated with a more severe impairment of QoL than HypoT in particular regarding physical functioning and HypoT+PT patients are hampered by impaired muscle function. Studies on how to improve well-being and muscle function in HypoT+PT patients are warranted.
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