Bone Abstracts

Background: Previous TBS studies in type 2 diabetes have suggested a deterioration of bone microarquitecture that could be related to a higher risk of fractures. However, there are no information in liver transplantation (LT) patients with new-onset diabetes after transplantation (NODAT).

Our aim was to investigate TBS in LT patients and the influence of NODAT in these patients. Also, we investigated the relationship between TBS and body composition parameters.

Methods: Sixty nine LT patients (age 57.9±10.5 years) were studied. BMI and waist perimeter were obtained in all patients. A 75 g oral glucose tolerance test was performed in non diabetic and ADA diagnostic criteria were followed. Lumbar and femoral BMD were measured with DXA densitometer (QDR 4500, Hologic, USA). TBS was calculated from DXA exam (TBS iNsight 2.0 software, Med-Imaps, Switzerland). Body composition parameters included total body mineral content (BMC), total fat mass (FM), total fat free mass (FFM) and percentage of fat mass (%FM).

Results: Thirty six percent of patients had impaired glucose tolerance (IGT), and 42% fulfilled NODAT criteria. TBS showed positive correlations with lumbar BMD (r=0.37, P<0.01), femoral neck BMD (r=0.31, P=0.01) total femoral BMD (r=0.25, P<0.05) and total BMC (r=0.32, P<0.01). An inverse correlation was found between TBS and BMI (r=−0.32, P<0.01) and FM (r=−0.26, P<0.05). We found statistical differences in waist perimeter and %FM between patients with normal tolerance, IGT and NODAT (P<0.05). However, no significant differences were found in TBS, lumbar or femoral BMD, BMC, FM or FFM.

Conclusion: In LT patients, TBS is related to fat mass parameters and BMD. With this technique, we have not found deterioration of bone microstructure in patients with NODAT.