ECTS2016 Poster Presentations Osteoporosis: evaluation and imaging (39 abstracts)
Dexamethasone produces both bone-loss and bone-spare effects in OPG−/− mice
Zhifeng Sheng , Yan Zhang , Yinhui Zhou , Xiyu Wu , Linqing Yuan , Yangna Ou , Eryuan Liao & Houde Zhou
Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, China.
The effects of dexamethasone on trabecular and cortical bone in OPG−/− mice were investigated in present study. Forty 6-month-old C57BL/6J female mice, including wt (n=20) and OPG knockout (OPG−/−, n=20), were randomdly divided into four groups and treated with either sterile normal saline or dexamethasone at 1 mg/kg by intramuscular injection 3 days per week. All mice were sacrificed at 4 weeks after these treatments. Sera were harvested for biochemical analysis, while the fourth lumber vertebrae and left tibia were scanned by microCT. It was found that there was no significant difference in either CTX or P1NP in each group. In WT mice, dexamethasone did not induce any changes of bone parameters. While in OPG−/− mice, dramatic bone loss and micro-structural deteriorations in both lumbar trabecular and tibial cortical bone were found. However, it was also found that dexamethasone improved bone volume fraction, Tb.Th, Tb.N and decreased Tb.Sp as well as SMI in the tibial trabecuae of OPG−/− mice. This was firstly showed us that except for the expectedly bone-loss, dexamethasone could produce bone-spare effects in OPG−/− mice at specified bone sites.
Article tools
My recent searches
My recently viewed abstracts
Authors
Bone Abstracts
ISSN 2052-1219 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more