Bone Abstracts

Introduction: Osteoporosis is a systemic skeletal disease characterized by low bone mass and micro-architectural deterioration of bone tissue leading to an increase in bone fragility and susceptibility to fracture. Bone is subject to the influence of exogenous and endogenous hormonal factors capable of modulating the activity of bone cells and mineralization, and also the mechanical stresses. Postmenopausal osteoporosis is the most common primitive osteoporosis. Its diagnosis requires the elimination of secondary and metabolic bone disease.

The objective of the study: Evaluate the clinical and laboratory profile, especially vitamin D, frequently low in the elderly in 70 patients followed in rheumatology for postmenopausal osteoporosis.

Materials and methods: Descriptive study conducted in patients followed in rheumatology for postmenopausal osteoporosis. Were excluded patients followed for secondary osteoporosis and those with osteoporosis densitometry discovery before menopause may sound on bone metabolism.

All patients underwent an interview and physical examination, a complete blood and urine calcium and phosphate. An analytical study was conducted and this thanks to statistical tests Student.

Results: They were 70 patients. The average age was 63 years with a standard deviation of 9.19. The average weight was 69 kg. The age of menopause was below 50 years to 75.70%, beyond the other cases. Nine fracture history were recorded. All patients were referred to bone under treatment, especially bisphosphonate orally. The median duration of prescription was 24 months. Mean serum calcium was 93 mg/l (S.D.=5.85), serum phosphorus in 37.66 mg/l (S.D.=5.27), urinary calcium of 24–125 mg/24 (S.D.=34.01), 25 (OH) Vitamin D to 25 ng/ml (6.30). However, 51.3% of patients were taking concomitant vitamin D supplementation treatment. Parathyroid hormone was 45 ng/ml (12.54). Renal function was normal.

Discussion: It appears from our study, significantly advanced age compared to the definition of the disease, which states that postmenopausal osteoporosis is related to the aging population. The average weight does not reflect the obesity of our population, it does not constitute a bias on vitamin D deficiency found. Laboratory tests, usually normal in osteoporosis are made in the interest rule out other bone diseases. By comparing the results found in our study and physiological values for each analysis, it is concluded that all are in the standards. Thus, the found results are statistically significant.

Conclusion: Postmenopausal osteoporosis is the most common benign bone diseases embrittling. The Vitamin D deficiency is common and is often associated. The introduction of a target bone treatment first requires the correction of bone metabolism disorder, normal in primary osteoporosis, and research of secondary osteopathy.